HPV6 E7

Accession: H002804

Protein: E7

Organism: Human papillomavirus type 6

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Mutation

531-600

601-700

701-800

801-827

Legend:same sensemissenseinsertiondeletion

Mutation type	Position	DESC	Disease	Reference
same sense	545	T → C	Disease: Condyloma acuminate Region : Sichuan	Ref
missense	685	A → T (Y → F)	Disease: Condyloma acuminate Region : Sichuan	Ref
same sense	824	A → C	Disease: Condyloma acuminate Region : Sichuan	Ref

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Domain&Motif

method	domain/motif name	position	length	description
CDD	PHA02776	531-824	294	E7 protein; Provisional
CDD	E7	537-815	279	E7 protein, Early protein;
MOTIF_SCAN		549-560	12
MOTIF_SCAN		624-635	12
MOTIF_SCAN		744-755	12
MOTIF_SCAN		708-725	18
MOTIF_SCAN		549-557	9
MOTIF_SCAN		537-815	279
MOTIF_SCAN		675-716	42
MOTIF_SCAN		537-815	279
INTERPROSCAN		537-812	276
INTERPROSCAN		531-824	294
MOTIF_SEAR_IN_PROT		531-824	294
MOTIF_SEAR_IN_PROT		537-815	279
MOTIF_SEAR_IN_PROT		537-812	276
PROSITE_SCAN		549-557	9
PROSITE_SCAN		549-560	12
PROSITE_SCAN		624-635	12
PROSITE_SCAN		708-725	18
PROSITE_SCAN		744-755	12
SBASE		531-815	285
TMPRED_SERVER		768-821	54
TMPRED_SERVER		774-827	54

Sequence

         .         .         .         .         .         .　　　　　G:590
atgcatggaagacatgttaccctaaaggatattgtattagacctgcaacctccagaccct　　　　　C:60
 M  H  G  R  H  V  T  L  K  D  I  V  L  D  L  Q  P  P  D  P 　　　　　P:20


         .         .         .         .         .         .　　　　　G:650
gtagggttacattgctatgagcaattagtagacagctcagaagatgaggtggacgaagtg　　　　　C:60
 V  G  L  H  C  Y  E  Q  L  V  D  S  S  E  D  E  V  D  E  V 　　　　　P:20


         .         .         .         .         .         .　　　　　G:710
gacggacaagattcacaacctttaaaacaacattaccaaatagtgacctgttgctgtgga　　　　　C:60
 D  G  Q  D  S  Q  P  L  K  Q  H  Y  Q  I  V  T  C  C  C  G 　　　　　P:20


         .         .         .         .         .         .　　　　　G:770
tgtgacagcaacgttcgactggttgtgcagtgtacagaaacagacatcagagaagtgcaa　　　　　C:60
 C  D  S  N  V  R  L  V  V  Q  C  T  E  T  D  I  R  E  V  Q 　　　　　P:20


         .         .         .         .         .          　　　　　G:827
cagcttctgttgggaacactaaacatagtgtgtcccatctgcgcaccgaagacataa   　　　　　C:57
 Q  L  L  L  G  T  L  N  I  V  C  P  I  C  A  P  K  T       　　　　　P:18

Legend:gene mutationamino acid mutation

DETAIL

DOMAIN & MUTATION