HPV59 E4

Accession: H001284

Uniprot: Q76QV7

Protein: E4

Organism: Human papillomavirus type 59

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Domain&Motif

method	domain/motif name	position	length	description
CDD	Pap_E4	3343-3612	270	E4 protein; This is is a family of Papillomavirus proteins, E4, coded for by ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known.
CDD	PHA03417	3283-3612	330	E4 protein; Provisional
CDD	PHA03416	3331-3612	282	hypothetical E4 protein; Provisional
MOTIF_SCAN		3445-3456	12
MOTIF_SCAN		3475-3486	12
MOTIF_SCAN		3571-3582	12
MOTIF_SCAN		3286-3303	18
MOTIF_SCAN		3583-3600	18
MOTIF_SCAN		3298-3306	9
MOTIF_SCAN		3361-3369	9
MOTIF_SCAN		3454-3462	9
MOTIF_SCAN		3571-3579	9
MOTIF_SCAN		3601-3609	9
MOTIF_SCAN		3343-3612	270
MOTIF_SCAN		3343-3612	270
INTERPROSCAN		3343-3612	270
MOTIF_SEAR_IN_PROT		3343-3612	270
MOTIF_SEAR_IN_PROT		3283-3612	330
MOTIF_SEAR_IN_PROT		3331-3612	282
MOTIF_SEAR_IN_PROT		3451-3609	159
MOTIF_SEAR_IN_PROT		3343-3612	270
PROSITE_SCAN		3286-3303	18
PROSITE_SCAN		3298-3306	9
PROSITE_SCAN		3361-3369	9
PROSITE_SCAN		3445-3456	12
PROSITE_SCAN		3454-3462	9
PROSITE_SCAN		3475-3486	12
PROSITE_SCAN		3571-3579	9
PROSITE_SCAN		3571-3582	12
PROSITE_SCAN		3583-3600	18
PROSITE_SCAN		3601-3609	9
SBASE		3343-3612	270
TMPRED_SERVER		3346-3399	54
TMPRED_SERVER		3349-3402	54

Sequence

         .         .         .         .         .         .　　　　　G:3327
atgatgccaaaaaatatgggactacagacaagtgggaagtgcattataatggcaaggtta　　　　　C:60
 M  M  P  K  N  M  G  L  Q  T  S  G  K  C  I  I  M  A  R  L 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3387
ttgattgttatgactctatgtgcagtaccagtgacgagcaagtatccactgctggatctt　　　　　C:60
 L  I  V  M  T  L  C  A  V  P  V  T  S  K  Y  P  L  L  D  L 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3447
ctgagcaactatcatacccctccgcaacgccccccgaagccacgtacttgggcccccaaa　　　　　C:60
 L  S  N  Y  H  T  P  P  Q  R  P  P  K  P  R  T  W  A  P  K 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3507
cgtggaaccgtcagacgaagactggaaagcgaccaagacagtgtggatacacacagcacc　　　　　C:60
 R  G  T  V  R  R  R  L  E  S  D  Q  D  S  V  D  T  H  S  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3567
ctcagtctaccagcgtgtcagtggactactgtgacaacccagtcgtccgtttgcatccag　　　　　C:60
 L  S  L  P  A  C  Q  W  T  T  V  T  T  Q  S  S  V  C  I  Q 　　　　　P:20


         .         .         .         .                    　　　　　G:3615
gcaacaacccgcgacggcacatcccttgcagtaacactacgcctataa            　　　　　C:48
 A  T  T  R  D  G  T  S  L  A  V  T  L  R  L                　　　　　P:15

DETAIL

DOMAIN & MUTATION