HPV18 E2

Accession: H000212
Uniprot: Q80B71
Protein: E2
Organism: Human papillomavirus type 18

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Domain&Motif

method domain/motif name position length description graphical view
CDDPPV_E2_N2832-3434603E2 (early) protein, N terminal;
CDDPPV_E2_C3678-3908231E2 (early) protein, C terminal;
MOTIF_SCAN2889-290012
MOTIF_SCAN3015-302612
MOTIF_SCAN3417-342812
MOTIF_SCAN3735-374612
MOTIF_SCAN2823-283412
MOTIF_SCAN2835-284612
MOTIF_SCAN3105-311612
MOTIF_SCAN3117-312812
MOTIF_SCAN3348-335912
MOTIF_SCAN3432-344312
MOTIF_SCAN3069-308618
MOTIF_SCAN3195-321218
MOTIF_SCAN3366-338318
MOTIF_SCAN3519-353618
MOTIF_SCAN3537-355418
MOTIF_SCAN3792-380918
MOTIF_SCAN2823-28319
MOTIF_SCAN2841-28499
MOTIF_SCAN3288-32969
MOTIF_SCAN3522-35309
MOTIF_SCAN3708-37169
MOTIF_SCAN3837-38459
MOTIF_SCAN3678-3908231
MOTIF_SCAN2832-3434603
MOTIF_SCAN3678-3908231
MOTIF_SCAN2832-3434603
INTERPROSCAN3636-3911276
INTERPROSCAN3678-3896219
INTERPROSCAN2832-3431600
INTERPROSCAN3675-3908234
INTERPROSCAN3132-3434303
INTERPROSCAN3669-3911243
INTERPROSCAN2832-3416585
MOTIF_SEAR_IN_PROT2832-3434603
MOTIF_SEAR_IN_PROT3678-3908231
MOTIF_SEAR_IN_PROT2832-3416585
MOTIF_SEAR_IN_PROT3678-3896219
PROSITE_SCAN2823-28319
PROSITE_SCAN2823-283412
PROSITE_SCAN2835-284612
PROSITE_SCAN2841-28499
PROSITE_SCAN2889-290012
PROSITE_SCAN3015-302612
PROSITE_SCAN3069-308618
PROSITE_SCAN3105-311612
PROSITE_SCAN3117-312812
PROSITE_SCAN3195-321218
PROSITE_SCAN3288-32969
PROSITE_SCAN3348-335912
PROSITE_SCAN3366-338318
PROSITE_SCAN3417-342812
PROSITE_SCAN3432-344312
PROSITE_SCAN3519-353618
PROSITE_SCAN3522-35309
PROSITE_SCAN3537-355418
PROSITE_SCAN3708-37169
PROSITE_SCAN3735-374612
PROSITE_SCAN3792-380918
PROSITE_SCAN3837-38459
SBASE2832-3434603
SBASE3489-3602114
SBASE3675-3908234
RADAR3186-323651
RADAR3237-3350114
RADAR3357-343781
TMPRED_SERVER3855-391460
TMPRED_SERVER3861-391454
UNIPROTKB2817-3431615
UNIPROTKB3672-3911240

Sequence

         .         .         .         .         .         .     G:2876
atgcagacaccgaaggaaaccctttcggaacgtttaagtgcgttgcaggacaaaatcata     C:60
M Q T P K E T L S E R L S A L Q D K I I      P:20


. . . . . .     G:2936
gaccactatgaaaatgacagtaaagacatagacagccaaatacagtattggcaactaata     C:60
D H Y E N D S K D I D S Q I Q Y W Q L I      P:20


. . . . . .     G:2996
cgttgggaaaatgcaatattctttgcagcaagggaacatggcatacagacattaaaccac     C:60
R W E N A I F F A A R E H G I Q T L N H      P:20


. . . . . .     G:3056
caggtggtgccagcctataacatttcaaaaagtaaagcacataaagctattgaactgcaa     C:60
Q V V P A Y N I S K S K A H K A I E L Q      P:20


. . . . . .     G:3116
atggccctacaaggccttgcacaaagtgcatacaaaaccgaggattggacactgcaagac     C:60
M A L Q G L A Q S A Y K T E D W T L Q D      P:20


. . . . . .     G:3176
acatgcgaggaactatggaatacagaacctactcactgctttaaaaaaggtggccaaaca     C:60
T C E E L W N T E P T H C F K K G G Q T      P:20


. . . . . .     G:3236
gtacaagtatattttgatggcaacaaagacaattgtatgacctatgtagcatgggacagt     C:60
V Q V Y F D G N K D N C M T Y V A W D S      P:20


. . . . . .     G:3296
gtgtattatatgactgatgcaggaacatgggacaaaacggctacctgtgtaagtcacagg     C:60
V Y Y M T D A G T W D K T A T C V S H R      P:20


. . . . . .     G:3356
ggattgtattatgtaaaggaagggtacaacacgttttatatagaatttaaaagtgaatgt     C:60
G L Y Y V K E G Y N T F Y I E F K S E C      P:20


. . . . . .     G:3416
gaaaaatatgggaacacaggtacgtgggaagtacattttgggaataatgtaattgattgt     C:60
E K Y G N T G T W E V H F G N N V I D C      P:20


. . . . . .     G:3476
aatgactctatgtgcagtaccagtgacgacacggtatccgctactcagcttgttaaacag     C:60
N D S M C S T S D D T V S A T Q L V K Q      P:20


. . . . . .     G:3536
ctacagcacaccccctcaccgtattccagcaccgtgtccgtgggcaccgcaaagacctac     C:60
L Q H T P S P Y S S T V S V G T A K T Y      P:20


. . . . . .     G:3596
ggccagacgtcggctgctacacgacctggacactgtggactcgcggagaagcagcattgt     C:60
G Q T S A A T R P G H C G L A E K Q H C      P:20


. . . . . .     G:3656
ggacctgtcaacccacttctcggtgcagctacacctacaggcaacaacaaaagacggaaa     C:60
G P V N P L L G A A T P T G N N K R R K      P:20


. . . . . .     G:3716
ctctgtagtggtaacactacgcctataatacatttaaaaggtgacagaaacagtttaaaa     C:60
L C S G N T T P I I H L K G D R N S L K      P:20


. . . . . .     G:3776
tgtttacggtacagattgcgaaaacatagcgaccactatagagatatatcatccacctgg     C:60
C L R Y R L R K H S D H Y R D I S S T W      P:20


. . . . . .     G:3836
cattggacaggtgcaggcaatgaaaaaacaggaatactgactgtaacataccatagtgaa     C:60
H W T G A G N E K T G I L T V T Y H S E      P:20


. . . . . .     G:3896
acacaaagaacaaaatttttaaatactgttgcaattccagatagtgtacaaatattggtg     C:60
T Q R T K F L N T V A I P D S V Q I L V      P:20


.      G:3914
ggatacatgacaatgtaa      C:18
G Y M T M      P:5


Structure&Mutation

2817
3914
Legend:HelixTurnBeta strandMutation
Feature keyPosition(s)Lengthgraphical view
Helix2826-289166
Helix2904-297269
Beta strand2982-29909
Helix3030-308051
Turn3084-309512
Turn3108-311912
Helix3123-313412
Beta strand3138-31469
Beta strand3153-319139
Beta strand3201-324848
Beta strand3264-327512
Beta strand3279-32879
Beta strand3291-331424
Beta strand3321-334121
Helix3342-335615
Beta strand3381-339515
Beta strand3675-370127
Helix3702-374342
Beta strand3756-376712
Turn3789-37979
Beta strand3804-382421
Helix3834-386330
Beta strand3882-390827