HPV18 E2
Accession: H000212
Uniprot: Q80B71
Protein: E2
Organism: Human papillomavirus type 18
Function
It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b
Domain&Motif
| method | domain/motif name | position | length | description | graphical view |
|---|---|---|---|---|---|
| CDD | PPV_E2_N | 2832-3434 | 603 | E2 (early) protein, N terminal; | |
| CDD | PPV_E2_C | 3678-3908 | 231 | E2 (early) protein, C terminal; | |
| MOTIF_SCAN | 2889-2900 | 12 | |||
| MOTIF_SCAN | 3015-3026 | 12 | |||
| MOTIF_SCAN | 3417-3428 | 12 | |||
| MOTIF_SCAN | 3735-3746 | 12 | |||
| MOTIF_SCAN | 2823-2834 | 12 | |||
| MOTIF_SCAN | 2835-2846 | 12 | |||
| MOTIF_SCAN | 3105-3116 | 12 | |||
| MOTIF_SCAN | 3117-3128 | 12 | |||
| MOTIF_SCAN | 3348-3359 | 12 | |||
| MOTIF_SCAN | 3432-3443 | 12 | |||
| MOTIF_SCAN | 3069-3086 | 18 | |||
| MOTIF_SCAN | 3195-3212 | 18 | |||
| MOTIF_SCAN | 3366-3383 | 18 | |||
| MOTIF_SCAN | 3519-3536 | 18 | |||
| MOTIF_SCAN | 3537-3554 | 18 | |||
| MOTIF_SCAN | 3792-3809 | 18 | |||
| MOTIF_SCAN | 2823-2831 | 9 | |||
| MOTIF_SCAN | 2841-2849 | 9 | |||
| MOTIF_SCAN | 3288-3296 | 9 | |||
| MOTIF_SCAN | 3522-3530 | 9 | |||
| MOTIF_SCAN | 3708-3716 | 9 | |||
| MOTIF_SCAN | 3837-3845 | 9 | |||
| MOTIF_SCAN | 3678-3908 | 231 | |||
| MOTIF_SCAN | 2832-3434 | 603 | |||
| MOTIF_SCAN | 3678-3908 | 231 | |||
| MOTIF_SCAN | 2832-3434 | 603 | |||
| INTERPROSCAN | 3636-3911 | 276 | |||
| INTERPROSCAN | 3678-3896 | 219 | |||
| INTERPROSCAN | 2832-3431 | 600 | |||
| INTERPROSCAN | 3675-3908 | 234 | |||
| INTERPROSCAN | 3132-3434 | 303 | |||
| INTERPROSCAN | 3669-3911 | 243 | |||
| INTERPROSCAN | 2832-3416 | 585 | |||
| MOTIF_SEAR_IN_PROT | 2832-3434 | 603 | |||
| MOTIF_SEAR_IN_PROT | 3678-3908 | 231 | |||
| MOTIF_SEAR_IN_PROT | 2832-3416 | 585 | |||
| MOTIF_SEAR_IN_PROT | 3678-3896 | 219 | |||
| PROSITE_SCAN | 2823-2831 | 9 | |||
| PROSITE_SCAN | 2823-2834 | 12 | |||
| PROSITE_SCAN | 2835-2846 | 12 | |||
| PROSITE_SCAN | 2841-2849 | 9 | |||
| PROSITE_SCAN | 2889-2900 | 12 | |||
| PROSITE_SCAN | 3015-3026 | 12 | |||
| PROSITE_SCAN | 3069-3086 | 18 | |||
| PROSITE_SCAN | 3105-3116 | 12 | |||
| PROSITE_SCAN | 3117-3128 | 12 | |||
| PROSITE_SCAN | 3195-3212 | 18 | |||
| PROSITE_SCAN | 3288-3296 | 9 | |||
| PROSITE_SCAN | 3348-3359 | 12 | |||
| PROSITE_SCAN | 3366-3383 | 18 | |||
| PROSITE_SCAN | 3417-3428 | 12 | |||
| PROSITE_SCAN | 3432-3443 | 12 | |||
| PROSITE_SCAN | 3519-3536 | 18 | |||
| PROSITE_SCAN | 3522-3530 | 9 | |||
| PROSITE_SCAN | 3537-3554 | 18 | |||
| PROSITE_SCAN | 3708-3716 | 9 | |||
| PROSITE_SCAN | 3735-3746 | 12 | |||
| PROSITE_SCAN | 3792-3809 | 18 | |||
| PROSITE_SCAN | 3837-3845 | 9 | |||
| SBASE | 2832-3434 | 603 | |||
| SBASE | 3489-3602 | 114 | |||
| SBASE | 3675-3908 | 234 | |||
| RADAR | 3186-3236 | 51 | |||
| RADAR | 3237-3350 | 114 | |||
| RADAR | 3357-3437 | 81 | |||
| TMPRED_SERVER | 3855-3914 | 60 | |||
| TMPRED_SERVER | 3861-3914 | 54 | |||
| UNIPROTKB | 2817-3431 | 615 | |||
| UNIPROTKB | 3672-3911 | 240 |
Sequence
. . . . . . G:2876
atgcagacaccgaaggaaaccctttcggaacgtttaagtgcgttgcaggacaaaatcata C:60
M Q T P K E T L S E R L S A L Q D K I I P:20
. . . . . . G:2936
gaccactatgaaaatgacagtaaagacatagacagccaaatacagtattggcaactaata C:60
D H Y E N D S K D I D S Q I Q Y W Q L I P:20
. . . . . . G:2996
cgttgggaaaatgcaatattctttgcagcaagggaacatggcatacagacattaaaccac C:60
R W E N A I F F A A R E H G I Q T L N H P:20
. . . . . . G:3056
caggtggtgccagcctataacatttcaaaaagtaaagcacataaagctattgaactgcaa C:60
Q V V P A Y N I S K S K A H K A I E L Q P:20
. . . . . . G:3116
atggccctacaaggccttgcacaaagtgcatacaaaaccgaggattggacactgcaagac C:60
M A L Q G L A Q S A Y K T E D W T L Q D P:20
. . . . . . G:3176
acatgcgaggaactatggaatacagaacctactcactgctttaaaaaaggtggccaaaca C:60
T C E E L W N T E P T H C F K K G G Q T P:20
. . . . . . G:3236
gtacaagtatattttgatggcaacaaagacaattgtatgacctatgtagcatgggacagt C:60
V Q V Y F D G N K D N C M T Y V A W D S P:20
. . . . . . G:3296
gtgtattatatgactgatgcaggaacatgggacaaaacggctacctgtgtaagtcacagg C:60
V Y Y M T D A G T W D K T A T C V S H R P:20
. . . . . . G:3356
ggattgtattatgtaaaggaagggtacaacacgttttatatagaatttaaaagtgaatgt C:60
G L Y Y V K E G Y N T F Y I E F K S E C P:20
. . . . . . G:3416
gaaaaatatgggaacacaggtacgtgggaagtacattttgggaataatgtaattgattgt C:60
E K Y G N T G T W E V H F G N N V I D C P:20
. . . . . . G:3476
aatgactctatgtgcagtaccagtgacgacacggtatccgctactcagcttgttaaacag C:60
N D S M C S T S D D T V S A T Q L V K Q P:20
. . . . . . G:3536
ctacagcacaccccctcaccgtattccagcaccgtgtccgtgggcaccgcaaagacctac C:60
L Q H T P S P Y S S T V S V G T A K T Y P:20
. . . . . . G:3596
ggccagacgtcggctgctacacgacctggacactgtggactcgcggagaagcagcattgt C:60
G Q T S A A T R P G H C G L A E K Q H C P:20
. . . . . . G:3656
ggacctgtcaacccacttctcggtgcagctacacctacaggcaacaacaaaagacggaaa C:60
G P V N P L L G A A T P T G N N K R R K P:20
. . . . . . G:3716
ctctgtagtggtaacactacgcctataatacatttaaaaggtgacagaaacagtttaaaa C:60
L C S G N T T P I I H L K G D R N S L K P:20
. . . . . . G:3776
tgtttacggtacagattgcgaaaacatagcgaccactatagagatatatcatccacctgg C:60
C L R Y R L R K H S D H Y R D I S S T W P:20
. . . . . . G:3836
cattggacaggtgcaggcaatgaaaaaacaggaatactgactgtaacataccatagtgaa C:60
H W T G A G N E K T G I L T V T Y H S E P:20
. . . . . . G:3896
acacaaagaacaaaatttttaaatactgttgcaattccagatagtgtacaaatattggtg C:60
T Q R T K F L N T V A I P D S V Q I L V P:20
. G:3914
ggatacatgacaatgtaa C:18
G Y M T M P:5
Structure&Mutation
2817
3914
Legend:HelixTurnBeta strand
Mutation
Mutation| Feature key | Position(s) | Length | graphical view |
|---|---|---|---|
| Helix | 2826-2891 | 66 | |
| Helix | 2904-2972 | 69 | |
| Beta strand | 2982-2990 | 9 | |
| Helix | 3030-3080 | 51 | |
| Turn | 3084-3095 | 12 | |
| Turn | 3108-3119 | 12 | |
| Helix | 3123-3134 | 12 | |
| Beta strand | 3138-3146 | 9 | |
| Beta strand | 3153-3191 | 39 | |
| Beta strand | 3201-3248 | 48 | |
| Beta strand | 3264-3275 | 12 | |
| Beta strand | 3279-3287 | 9 | |
| Beta strand | 3291-3314 | 24 | |
| Beta strand | 3321-3341 | 21 | |
| Helix | 3342-3356 | 15 | |
| Beta strand | 3381-3395 | 15 | |
| Beta strand | 3675-3701 | 27 | |
| Helix | 3702-3743 | 42 | |
| Beta strand | 3756-3767 | 12 | |
| Turn | 3789-3797 | 9 | |
| Beta strand | 3804-3824 | 21 | |
| Helix | 3834-3863 | 30 | |
| Beta strand | 3882-3908 | 27 |
