HPV18 E1
Accession: H000199
Uniprot: Q80B72
Protein: E1
Organism: Human papillomavirus type 18
Function
ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein.
Domain&Motif
| method | domain/motif name | position | length | description | graphical view |
|---|---|---|---|---|---|
| CDD | PPV_E1_C | 1565-2857 | 1293 | Papillomavirus helicase; This protein is a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508. | |
| CDD | PPV_E1_N | 914-1342 | 429 | E1 Protein, N terminal domain; | |
| CDD | Parvo_NS1 | 2255-2791 | 537 | Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splic | |
| CDD | PHA02774 | 914-2884 | 1971 | E1; Provisional | |
| MOTIF_SCAN | 1028-1039 | 12 | |||
| MOTIF_SCAN | 1439-1450 | 12 | |||
| MOTIF_SCAN | 1916-1927 | 12 | |||
| MOTIF_SCAN | 2195-2206 | 12 | |||
| MOTIF_SCAN | 2441-2452 | 12 | |||
| MOTIF_SCAN | 2363-2386 | 24 | |||
| MOTIF_SCAN | 932-943 | 12 | |||
| MOTIF_SCAN | 1010-1021 | 12 | |||
| MOTIF_SCAN | 1040-1051 | 12 | |||
| MOTIF_SCAN | 1079-1090 | 12 | |||
| MOTIF_SCAN | 1304-1315 | 12 | |||
| MOTIF_SCAN | 1331-1342 | 12 | |||
| MOTIF_SCAN | 1364-1375 | 12 | |||
| MOTIF_SCAN | 1445-1456 | 12 | |||
| MOTIF_SCAN | 1472-1483 | 12 | |||
| MOTIF_SCAN | 1586-1597 | 12 | |||
| MOTIF_SCAN | 1628-1639 | 12 | |||
| MOTIF_SCAN | 1670-1681 | 12 | |||
| MOTIF_SCAN | 1991-2002 | 12 | |||
| MOTIF_SCAN | 2225-2236 | 12 | |||
| MOTIF_SCAN | 2522-2533 | 12 | |||
| MOTIF_SCAN | 2684-2695 | 12 | |||
| MOTIF_SCAN | 2786-2797 | 12 | |||
| MOTIF_SCAN | 944-961 | 18 | |||
| MOTIF_SCAN | 1187-1204 | 18 | |||
| MOTIF_SCAN | 1274-1291 | 18 | |||
| MOTIF_SCAN | 1379-1396 | 18 | |||
| MOTIF_SCAN | 1400-1417 | 18 | |||
| MOTIF_SCAN | 1424-1441 | 18 | |||
| MOTIF_SCAN | 1457-1474 | 18 | |||
| MOTIF_SCAN | 1547-1564 | 18 | |||
| MOTIF_SCAN | 1580-1597 | 18 | |||
| MOTIF_SCAN | 1658-1675 | 18 | |||
| MOTIF_SCAN | 1979-1996 | 18 | |||
| MOTIF_SCAN | 2306-2323 | 18 | |||
| MOTIF_SCAN | 2420-2437 | 18 | |||
| MOTIF_SCAN | 2558-2575 | 18 | |||
| MOTIF_SCAN | 2831-2848 | 18 | |||
| MOTIF_SCAN | 1241-1249 | 9 | |||
| MOTIF_SCAN | 1616-1624 | 9 | |||
| MOTIF_SCAN | 2333-2341 | 9 | |||
| MOTIF_SCAN | 2375-2383 | 9 | |||
| MOTIF_SCAN | 2846-2854 | 9 | |||
| MOTIF_SCAN | 2285-2737 | 453 | |||
| MOTIF_SCAN | 1070-1105 | 36 | |||
| MOTIF_SCAN | 1562-2857 | 1296 | |||
| MOTIF_SCAN | 914-1342 | 429 | |||
| MOTIF_SCAN | 2339-2389 | 51 | |||
| MOTIF_SCAN | 1562-2857 | 1296 | |||
| MOTIF_SCAN | 914-1342 | 429 | |||
| INTERPROSCAN | 914-2884 | 1971 | |||
| INTERPROSCAN | 2186-2800 | 615 | |||
| INTERPROSCAN | 2285-2737 | 453 | |||
| INTERPROSCAN | 914-1333 | 420 | |||
| INTERPROSCAN | 1565-2857 | 1293 | |||
| INTERPROSCAN | 2171-2803 | 633 | |||
| PROSITE_AT_ExPASy | 2285-2737 | 453 | |||
| MOTIF_SEAR_IN_PROT | 2285-2737 | 453 | |||
| MOTIF_SEAR_IN_PROT | 914-2884 | 1971 | |||
| MOTIF_SEAR_IN_PROT | 1565-2857 | 1293 | |||
| MOTIF_SEAR_IN_PROT | 914-1342 | 429 | |||
| MOTIF_SEAR_IN_PROT | 2255-2635 | 381 | |||
| MOTIF_SEAR_IN_PROT | 2354-2587 | 234 | |||
| MOTIF_SEAR_IN_PROT | 2303-2443 | 141 | |||
| MOTIF_SEAR_IN_PROT | 1565-2857 | 1293 | |||
| MOTIF_SEAR_IN_PROT | 914-1333 | 420 | |||
| MOTIF_SEAR_IN_PROT | 2252-2635 | 384 | |||
| MOTIF_SEAR_IN_PROT | 2354-2509 | 156 | |||
| PROSITE_SCAN | 932-943 | 12 | |||
| PROSITE_SCAN | 944-961 | 18 | |||
| PROSITE_SCAN | 1010-1021 | 12 | |||
| PROSITE_SCAN | 1028-1039 | 12 | |||
| PROSITE_SCAN | 1040-1051 | 12 | |||
| PROSITE_SCAN | 1079-1090 | 12 | |||
| PROSITE_SCAN | 1187-1204 | 18 | |||
| PROSITE_SCAN | 1241-1249 | 9 | |||
| PROSITE_SCAN | 1274-1291 | 18 | |||
| PROSITE_SCAN | 1304-1315 | 12 | |||
| PROSITE_SCAN | 1331-1342 | 12 | |||
| PROSITE_SCAN | 1364-1375 | 12 | |||
| PROSITE_SCAN | 1379-1396 | 18 | |||
| PROSITE_SCAN | 1400-1417 | 18 | |||
| PROSITE_SCAN | 1424-1441 | 18 | |||
| PROSITE_SCAN | 1439-1450 | 12 | |||
| PROSITE_SCAN | 1445-1456 | 12 | |||
| PROSITE_SCAN | 1457-1474 | 18 | |||
| PROSITE_SCAN | 1472-1483 | 12 | |||
| PROSITE_SCAN | 1547-1564 | 18 | |||
| PROSITE_SCAN | 1580-1597 | 18 | |||
| PROSITE_SCAN | 1586-1597 | 12 | |||
| PROSITE_SCAN | 1616-1624 | 9 | |||
| PROSITE_SCAN | 1628-1639 | 12 | |||
| PROSITE_SCAN | 1658-1675 | 18 | |||
| PROSITE_SCAN | 1670-1681 | 12 | |||
| PROSITE_SCAN | 1916-1927 | 12 | |||
| PROSITE_SCAN | 1979-1996 | 18 | |||
| PROSITE_SCAN | 1991-2002 | 12 | |||
| PROSITE_SCAN | 2195-2206 | 12 | |||
| PROSITE_SCAN | 2225-2236 | 12 | |||
| PROSITE_SCAN | 2285-2737 | 453 | |||
| PROSITE_SCAN | 2306-2323 | 18 | |||
| PROSITE_SCAN | 2333-2341 | 9 | |||
| PROSITE_SCAN | 2363-2386 | 24 | |||
| PROSITE_SCAN | 2375-2383 | 9 | |||
| PROSITE_SCAN | 2420-2437 | 18 | |||
| PROSITE_SCAN | 2441-2452 | 12 | |||
| PROSITE_SCAN | 2522-2533 | 12 | |||
| PROSITE_SCAN | 2558-2575 | 18 | |||
| PROSITE_SCAN | 2684-2695 | 12 | |||
| PROSITE_SCAN | 2786-2797 | 12 | |||
| PROSITE_SCAN | 2831-2848 | 18 | |||
| PROSITE_SCAN | 2846-2854 | 9 | |||
| SBASE | 914-1342 | 429 | |||
| SBASE | 1565-2857 | 1293 | |||
| RADAR | 1577-1735 | 159 | |||
| RADAR | 1745-1891 | 147 | |||
| RADAR | 2267-2392 | 126 | |||
| RADAR | 2402-2530 | 129 | |||
| RADAR | 2534-2611 | 78 | |||
| RADAR | 2702-2767 | 66 | |||
| RADAR | 2780-2857 | 78 | |||
| TMPRED_SERVER | 1628-1690 | 63 | |||
| TMPRED_SERVER | 1634-1690 | 57 | |||
| TMPRED_SERVER | 1664-1720 | 57 | |||
| TMPRED_SERVER | 1712-1765 | 54 | |||
| TMPRED_SERVER | 1727-1780 | 54 | |||
| TMPRED_SERVER | 2387-2437 | 51 | |||
| TMPRED_SERVER | 2396-2446 | 51 | |||
| UNIPROTKB | 2363-2386 | 24 | |||
| UNIPROTKB | 2363-2386 | 24 | |||
| UNIPROTKB | 1352-2245 | 894 | |||
| UNIPROTKB | 1490-1990 | 501 | |||
| UNIPROTKB | 1169-1177 | 9 | |||
| UNIPROTKB | 1238-1267 | 30 |
Sequence
. . . . . . G:973
atggctgatccagaaggtacagacggggagggcacgggttgtaacggctggttttatgta C:60
M A D P E G T D G E G T G C N G W F Y V P:20
. . . . . . G:1033
caagctattgtagacaaaaaaacaggagatgtaatatcagatgacgaggacgaaaatgca C:60
Q A I V D K K T G D V I S D D E D E N A P:20
. . . . . . G:1093
acagacacagggtcggatatggtagattttattgatacacaaggaacattttgtgaacag C:60
T D T G S D M V D F I D T Q G T F C E Q P:20
. . . . . . G:1153
gcagagctagagacagcacaggcattgttccatgcgcaggaggtccacaatgatgcacaa C:60
A E L E T A Q A L F H A Q E V H N D A Q P:20
. . . . . . G:1213
gtgttgcatgttttaaaacgaaagtttgcaggaggcagcacagaaaacagtccattaggg C:60
V L H V L K R K F A G G S T E N S P L G P:20
. . . . . . G:1273
gagcggctggaggtggatacagagttaagtccacggttacaagaaatatctttaaatagt C:60
E R L E V D T E L S P R L Q E I S L N S P:20
. . . . . . G:1333
gggcagaaaaaggcaaaaaggcggctgtttacaatatcagatagtggctatggctgttct C:60
G Q K K A K R R L F T I S D S G Y G C S P:20
. . . . . . G:1393
gaagtggaagcaacacagattcaggtaactacaaatggcgaacatggcggcaatgtatgt C:60
E V E A T Q I Q V T T N G E H G G N V C P:20
. . . . . . G:1453
agtggcggcagtacggaggctatagacaacgggggcacagagggcaacaacagcagtgta C:60
S G G S T E A I D N G G T E G N N S S V P:20
. . . . . . G:1513
gacggtacaagtgacaatagcaatatagaaaatgtaaatccacaatgtaccatagcacaa C:60
D G T S D N S N I E N V N P Q C T I A Q P:20
. . . . . . G:1573
ttaaaagacttgttaaaagtaaacaataaacaaggagctatgttagcagtatttaaagac C:60
L K D L L K V N N K Q G A M L A V F K D P:20
. . . . . . G:1633
acatatgggctatcatttacagatttagttagaaattttaaaagtgataaaaccacgtgt C:60
T Y G L S F T D L V R N F K S D K T T C P:20
. . . . . . G:1693
acagattgggttacagctatatttggagtaaacccaacaatagcagaaggatttaaaaca C:60
T D W V T A I F G V N P T I A E G F K T P:20
. . . . . . G:1753
ctaatacagccatttatattatatgcccatattcaatgtctagactgtaaatggggagta C:60
L I Q P F I L Y A H I Q C L D C K W G V P:20
. . . . . . G:1813
ttaatattagccctgttgcgttacaaatgtggtaagagtagactaacagttgctaaaggt C:60
L I L A L L R Y K C G K S R L T V A K G P:20
. . . . . . G:1873
ttaagtacgttgttacacgtacctgaaacttgtatgttaattcaaccaccaaaattgcga C:60
L S T L L H V P E T C M L I Q P P K L R P:20
. . . . . . G:1933
agtagtgttgcagcactatattggtatagaacaggaatatcaaatattagtgaagtaatg C:60
S S V A A L Y W Y R T G I S N I S E V M P:20
. . . . . . G:1993
ggagacacacctgagtggatacaaagacttactattatacaacatggaatagatgatagc C:60
G D T P E W I Q R L T I I Q H G I D D S P:20
. . . . . . G:2053
aattttgatttgtcagaaatggtacaatgggcatttgataatgagctgacagatgaaagc C:60
N F D L S E M V Q W A F D N E L T D E S P:20
. . . . . . G:2113
gatatggcatttgaatatgccttattagcagacagcaacagcaatgcagctgccttttta C:60
D M A F E Y A L L A D S N S N A A A F L P:20
. . . . . . G:2173
aaaagcaattgccaagctaaatatttaaaagattgtgccacaatgtgcaaacattatagg C:60
K S N C Q A K Y L K D C A T M C K H Y R P:20
. . . . . . G:2233
cgagcccaaaaacgacaaatgaatatgtcacagtggatacgatttagatgttcaaaaata C:60
R A Q K R Q M N M S Q W I R F R C S K I P:20
. . . . . . G:2293
gatgaagggggagattggagaccaatagtgcaattcctgcgataccaacaaatagagttt C:60
D E G G D W R P I V Q F L R Y Q Q I E F P:20
. . . . . . G:2353
ataacatttttaggagccttaaaatcatttttaaaaggaacccccaaaaaaaattgttta C:60
I T F L G A L K S F L K G T P K K N C L P:20
. . . . . . G:2413
gtattttgtggaccagcaaatacaggaaaatcatattttggaatgagttttatacacttt C:60
V F C G P A N T G K S Y F G M S F I H F P:20
. . . . . . G:2473
atacaaggagcagtaatatcatttgtgaattccactagtcatttttggttggaaccgtta C:60
I Q G A V I S F V N S T S H F W L E P L P:20
. . . . . . G:2533
acagatactaaggtggccatgttagatgatgcaacgaccacgtgttggacatactttgat C:60
T D T K V A M L D D A T T T C W T Y F D P:20
. . . . . . G:2593
acctatatgagaaatgcgttagatggcaatccaataagtattgatagaaagcacaaacca C:60
T Y M R N A L D G N P I S I D R K H K P P:20
. . . . . . G:2653
ttaatacaactaaaatgtcctccaatactactaaccacaaatatacatccagcaaaggat C:60
L I Q L K C P P I L L T T N I H P A K D P:20
. . . . . . G:2713
aatagatggccatatttagaaagtagaataacagtatttgaatttccaaatgcatttcca C:60
N R W P Y L E S R I T V F E F P N A F P P:20
. . . . . . G:2773
tttgataaaaatggcaatccagtatatgaaataaatgacaaaaattggaaatgttttttt C:60
F D K N G N P V Y E I N D K N W K C F F P:20
. . . . . . G:2833
gaaaggacatggtccagattagatttgcacgaggaagaggaagatgcagacaccgaagga C:60
E R T W S R L D L H E E E E D A D T E G P:20
. . . . . G:2887
aaccctttcggaacgtttaagtgcgttgcaggacaaaatcatagaccactatga C:54
N P F G T F K C V A G Q N H R P L P:17
Structure&Mutation
914
2887
Legend:HelixTurnBeta strand
Mutation
Mutation| Feature key | Position(s) | Length | graphical view |
|---|---|---|---|
| Helix | 1544-1579 | 36 | |
| Helix | 1589-1597 | 9 | |
| Beta strand | 1631-1663 | 33 | |
| Helix | 1667-1681 | 15 | |
| Helix | 1685-1699 | 15 | |
| Helix | 1700-1708 | 9 | |
| Beta strand | 1709-1741 | 33 | |
| Beta strand | 1748-1789 | 42 | |
| Helix | 1793-1828 | 36 | |
| Helix | 1838-1846 | 9 | |
| Beta strand | 1847-1858 | 12 | |
| Helix | 1877-1912 | 36 | |
| Beta strand | 1922-1936 | 15 | |
| Helix | 1946-1963 | 18 | |
| Helix | 2198-2227 | 30 | |
| Helix | 2252-2278 | 27 | |
| Helix | 2291-2329 | 39 | |
| Beta strand | 2345-2365 | 21 | |
| Helix | 2369-2377 | 9 | |
| Helix | 2381-2416 | 36 | |
| Beta strand | 2444-2452 | 9 | |
| Helix | 2456-2473 | 18 | |
| Beta strand | 2483-2506 | 24 | |
| Helix | 2510-2539 | 30 | |
| Helix | 2543-2557 | 15 | |
| Beta strand | 2567-2575 | 9 | |
| Beta strand | 2582-2590 | 9 | |
| Beta strand | 2597-2605 | 9 | |
| Beta strand | 2618-2638 | 21 | |
| Beta strand | 2648-2659 | 12 | |
| Helix | 2663-2674 | 12 | |
| Beta strand | 2684-2695 | 12 | |
| Helix | 2750-2782 | 33 | |
| Helix | 2786-2794 | 9 |
