HPV18 E1

Accession: H000199
Uniprot: Q80B72
Protein: E1
Organism: Human papillomavirus type 18

Function

ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein.

Domain&Motif

method domain/motif name position length description graphical view
CDDPPV_E1_C1565-28571293Papillomavirus helicase; This protein is a DNA helicase that is required for initiation of viral DNA replication. This protein forms a complex with the E2 protein pfam00508.
CDDPPV_E1_N914-1342429E1 Protein, N terminal domain;
CDDParvo_NS12255-2791537Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splic
CDDPHA02774914-28841971E1; Provisional
MOTIF_SCAN1028-103912
MOTIF_SCAN1439-145012
MOTIF_SCAN1916-192712
MOTIF_SCAN2195-220612
MOTIF_SCAN2441-245212
MOTIF_SCAN2363-238624
MOTIF_SCAN932-94312
MOTIF_SCAN1010-102112
MOTIF_SCAN1040-105112
MOTIF_SCAN1079-109012
MOTIF_SCAN1304-131512
MOTIF_SCAN1331-134212
MOTIF_SCAN1364-137512
MOTIF_SCAN1445-145612
MOTIF_SCAN1472-148312
MOTIF_SCAN1586-159712
MOTIF_SCAN1628-163912
MOTIF_SCAN1670-168112
MOTIF_SCAN1991-200212
MOTIF_SCAN2225-223612
MOTIF_SCAN2522-253312
MOTIF_SCAN2684-269512
MOTIF_SCAN2786-279712
MOTIF_SCAN944-96118
MOTIF_SCAN1187-120418
MOTIF_SCAN1274-129118
MOTIF_SCAN1379-139618
MOTIF_SCAN1400-141718
MOTIF_SCAN1424-144118
MOTIF_SCAN1457-147418
MOTIF_SCAN1547-156418
MOTIF_SCAN1580-159718
MOTIF_SCAN1658-167518
MOTIF_SCAN1979-199618
MOTIF_SCAN2306-232318
MOTIF_SCAN2420-243718
MOTIF_SCAN2558-257518
MOTIF_SCAN2831-284818
MOTIF_SCAN1241-12499
MOTIF_SCAN1616-16249
MOTIF_SCAN2333-23419
MOTIF_SCAN2375-23839
MOTIF_SCAN2846-28549
MOTIF_SCAN2285-2737453
MOTIF_SCAN1070-110536
MOTIF_SCAN1562-28571296
MOTIF_SCAN914-1342429
MOTIF_SCAN2339-238951
MOTIF_SCAN1562-28571296
MOTIF_SCAN914-1342429
INTERPROSCAN914-28841971
INTERPROSCAN2186-2800615
INTERPROSCAN2285-2737453
INTERPROSCAN914-1333420
INTERPROSCAN1565-28571293
INTERPROSCAN2171-2803633
PROSITE_AT_ExPASy2285-2737453
MOTIF_SEAR_IN_PROT2285-2737453
MOTIF_SEAR_IN_PROT914-28841971
MOTIF_SEAR_IN_PROT1565-28571293
MOTIF_SEAR_IN_PROT914-1342429
MOTIF_SEAR_IN_PROT2255-2635381
MOTIF_SEAR_IN_PROT2354-2587234
MOTIF_SEAR_IN_PROT2303-2443141
MOTIF_SEAR_IN_PROT1565-28571293
MOTIF_SEAR_IN_PROT914-1333420
MOTIF_SEAR_IN_PROT2252-2635384
MOTIF_SEAR_IN_PROT2354-2509156
PROSITE_SCAN932-94312
PROSITE_SCAN944-96118
PROSITE_SCAN1010-102112
PROSITE_SCAN1028-103912
PROSITE_SCAN1040-105112
PROSITE_SCAN1079-109012
PROSITE_SCAN1187-120418
PROSITE_SCAN1241-12499
PROSITE_SCAN1274-129118
PROSITE_SCAN1304-131512
PROSITE_SCAN1331-134212
PROSITE_SCAN1364-137512
PROSITE_SCAN1379-139618
PROSITE_SCAN1400-141718
PROSITE_SCAN1424-144118
PROSITE_SCAN1439-145012
PROSITE_SCAN1445-145612
PROSITE_SCAN1457-147418
PROSITE_SCAN1472-148312
PROSITE_SCAN1547-156418
PROSITE_SCAN1580-159718
PROSITE_SCAN1586-159712
PROSITE_SCAN1616-16249
PROSITE_SCAN1628-163912
PROSITE_SCAN1658-167518
PROSITE_SCAN1670-168112
PROSITE_SCAN1916-192712
PROSITE_SCAN1979-199618
PROSITE_SCAN1991-200212
PROSITE_SCAN2195-220612
PROSITE_SCAN2225-223612
PROSITE_SCAN2285-2737453
PROSITE_SCAN2306-232318
PROSITE_SCAN2333-23419
PROSITE_SCAN2363-238624
PROSITE_SCAN2375-23839
PROSITE_SCAN2420-243718
PROSITE_SCAN2441-245212
PROSITE_SCAN2522-253312
PROSITE_SCAN2558-257518
PROSITE_SCAN2684-269512
PROSITE_SCAN2786-279712
PROSITE_SCAN2831-284818
PROSITE_SCAN2846-28549
SBASE914-1342429
SBASE1565-28571293
RADAR1577-1735159
RADAR1745-1891147
RADAR2267-2392126
RADAR2402-2530129
RADAR2534-261178
RADAR2702-276766
RADAR2780-285778
TMPRED_SERVER1628-169063
TMPRED_SERVER1634-169057
TMPRED_SERVER1664-172057
TMPRED_SERVER1712-176554
TMPRED_SERVER1727-178054
TMPRED_SERVER2387-243751
TMPRED_SERVER2396-244651
UNIPROTKB2363-238624
UNIPROTKB2363-238624
UNIPROTKB1352-2245894
UNIPROTKB1490-1990501
UNIPROTKB1169-11779
UNIPROTKB1238-126730

Sequence

         .         .         .         .         .         .     G:973
atggctgatccagaaggtacagacggggagggcacgggttgtaacggctggttttatgta     C:60
M A D P E G T D G E G T G C N G W F Y V      P:20


. . . . . .     G:1033
caagctattgtagacaaaaaaacaggagatgtaatatcagatgacgaggacgaaaatgca     C:60
Q A I V D K K T G D V I S D D E D E N A      P:20


. . . . . .     G:1093
acagacacagggtcggatatggtagattttattgatacacaaggaacattttgtgaacag     C:60
T D T G S D M V D F I D T Q G T F C E Q      P:20


. . . . . .     G:1153
gcagagctagagacagcacaggcattgttccatgcgcaggaggtccacaatgatgcacaa     C:60
A E L E T A Q A L F H A Q E V H N D A Q      P:20


. . . . . .     G:1213
gtgttgcatgttttaaaacgaaagtttgcaggaggcagcacagaaaacagtccattaggg     C:60
V L H V L K R K F A G G S T E N S P L G      P:20


. . . . . .     G:1273
gagcggctggaggtggatacagagttaagtccacggttacaagaaatatctttaaatagt     C:60
E R L E V D T E L S P R L Q E I S L N S      P:20


. . . . . .     G:1333
gggcagaaaaaggcaaaaaggcggctgtttacaatatcagatagtggctatggctgttct     C:60
G Q K K A K R R L F T I S D S G Y G C S      P:20


. . . . . .     G:1393
gaagtggaagcaacacagattcaggtaactacaaatggcgaacatggcggcaatgtatgt     C:60
E V E A T Q I Q V T T N G E H G G N V C      P:20


. . . . . .     G:1453
agtggcggcagtacggaggctatagacaacgggggcacagagggcaacaacagcagtgta     C:60
S G G S T E A I D N G G T E G N N S S V      P:20


. . . . . .     G:1513
gacggtacaagtgacaatagcaatatagaaaatgtaaatccacaatgtaccatagcacaa     C:60
D G T S D N S N I E N V N P Q C T I A Q      P:20


. . . . . .     G:1573
ttaaaagacttgttaaaagtaaacaataaacaaggagctatgttagcagtatttaaagac     C:60
L K D L L K V N N K Q G A M L A V F K D      P:20


. . . . . .     G:1633
acatatgggctatcatttacagatttagttagaaattttaaaagtgataaaaccacgtgt     C:60
T Y G L S F T D L V R N F K S D K T T C      P:20


. . . . . .     G:1693
acagattgggttacagctatatttggagtaaacccaacaatagcagaaggatttaaaaca     C:60
T D W V T A I F G V N P T I A E G F K T      P:20


. . . . . .     G:1753
ctaatacagccatttatattatatgcccatattcaatgtctagactgtaaatggggagta     C:60
L I Q P F I L Y A H I Q C L D C K W G V      P:20


. . . . . .     G:1813
ttaatattagccctgttgcgttacaaatgtggtaagagtagactaacagttgctaaaggt     C:60
L I L A L L R Y K C G K S R L T V A K G      P:20


. . . . . .     G:1873
ttaagtacgttgttacacgtacctgaaacttgtatgttaattcaaccaccaaaattgcga     C:60
L S T L L H V P E T C M L I Q P P K L R      P:20


. . . . . .     G:1933
agtagtgttgcagcactatattggtatagaacaggaatatcaaatattagtgaagtaatg     C:60
S S V A A L Y W Y R T G I S N I S E V M      P:20


. . . . . .     G:1993
ggagacacacctgagtggatacaaagacttactattatacaacatggaatagatgatagc     C:60
G D T P E W I Q R L T I I Q H G I D D S      P:20


. . . . . .     G:2053
aattttgatttgtcagaaatggtacaatgggcatttgataatgagctgacagatgaaagc     C:60
N F D L S E M V Q W A F D N E L T D E S      P:20


. . . . . .     G:2113
gatatggcatttgaatatgccttattagcagacagcaacagcaatgcagctgccttttta     C:60
D M A F E Y A L L A D S N S N A A A F L      P:20


. . . . . .     G:2173
aaaagcaattgccaagctaaatatttaaaagattgtgccacaatgtgcaaacattatagg     C:60
K S N C Q A K Y L K D C A T M C K H Y R      P:20


. . . . . .     G:2233
cgagcccaaaaacgacaaatgaatatgtcacagtggatacgatttagatgttcaaaaata     C:60
R A Q K R Q M N M S Q W I R F R C S K I      P:20


. . . . . .     G:2293
gatgaagggggagattggagaccaatagtgcaattcctgcgataccaacaaatagagttt     C:60
D E G G D W R P I V Q F L R Y Q Q I E F      P:20


. . . . . .     G:2353
ataacatttttaggagccttaaaatcatttttaaaaggaacccccaaaaaaaattgttta     C:60
I T F L G A L K S F L K G T P K K N C L      P:20


. . . . . .     G:2413
gtattttgtggaccagcaaatacaggaaaatcatattttggaatgagttttatacacttt     C:60
V F C G P A N T G K S Y F G M S F I H F      P:20


. . . . . .     G:2473
atacaaggagcagtaatatcatttgtgaattccactagtcatttttggttggaaccgtta     C:60
I Q G A V I S F V N S T S H F W L E P L      P:20


. . . . . .     G:2533
acagatactaaggtggccatgttagatgatgcaacgaccacgtgttggacatactttgat     C:60
T D T K V A M L D D A T T T C W T Y F D      P:20


. . . . . .     G:2593
acctatatgagaaatgcgttagatggcaatccaataagtattgatagaaagcacaaacca     C:60
T Y M R N A L D G N P I S I D R K H K P      P:20


. . . . . .     G:2653
ttaatacaactaaaatgtcctccaatactactaaccacaaatatacatccagcaaaggat     C:60
L I Q L K C P P I L L T T N I H P A K D      P:20


. . . . . .     G:2713
aatagatggccatatttagaaagtagaataacagtatttgaatttccaaatgcatttcca     C:60
N R W P Y L E S R I T V F E F P N A F P      P:20


. . . . . .     G:2773
tttgataaaaatggcaatccagtatatgaaataaatgacaaaaattggaaatgttttttt     C:60
F D K N G N P V Y E I N D K N W K C F F      P:20


. . . . . .     G:2833
gaaaggacatggtccagattagatttgcacgaggaagaggaagatgcagacaccgaagga     C:60
E R T W S R L D L H E E E E D A D T E G      P:20


. . . . .      G:2887
aaccctttcggaacgtttaagtgcgttgcaggacaaaatcatagaccactatga      C:54
N P F G T F K C V A G Q N H R P L      P:17


Structure&Mutation

914
2887
Legend:HelixTurnBeta strandMutation
Feature keyPosition(s)Lengthgraphical view
Helix1544-157936
Helix1589-15979
Beta strand1631-166333
Helix1667-168115
Helix1685-169915
Helix1700-17089
Beta strand1709-174133
Beta strand1748-178942
Helix1793-182836
Helix1838-18469
Beta strand1847-185812
Helix1877-191236
Beta strand1922-193615
Helix1946-196318
Helix2198-222730
Helix2252-227827
Helix2291-232939
Beta strand2345-236521
Helix2369-23779
Helix2381-241636
Beta strand2444-24529
Helix2456-247318
Beta strand2483-250624
Helix2510-253930
Helix2543-255715
Beta strand2567-25759
Beta strand2582-25909
Beta strand2597-26059
Beta strand2618-263821
Beta strand2648-265912
Helix2663-267412
Beta strand2684-269512
Helix2750-278233
Helix2786-27949