HPV18 E7
Accession: H000197
NC: NP_040311.1
Uniprot: Q76Z96
Protein: E7
Organism: Human papillomavirus type 18
Function
E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.
Mutation
590-600
601-700
701-800
801-900
901-907
Legend:same sensemissenseinsertiondeletion
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Domain&Motif
| method | domain/motif name | position | length | description | graphical view |
|---|---|---|---|---|---|
| CDD | E7 | 596-895 | 300 | E7 protein, Early protein; |  |
| CDD | PHA02776 | 590-901 | 312 | E7 protein; Provisional | |
| MOTIF_SCAN | 608-619 | 12 | | ||
| MOTIF_SCAN | 683-694 | 12 | | ||
| MOTIF_SCAN | 821-832 | 12 | | ||
| MOTIF_SCAN | 776-904 | 129 | | ||
| MOTIF_SCAN | 596-895 | 300 | | ||
| MOTIF_SCAN | 596-895 | 300 | | ||
| INTERPROSCAN | 596-892 | 297 | | ||
| INTERPROSCAN | 590-904 | 315 | | ||
| MOTIF_SEAR_IN_PROT | 596-895 | 300 | | ||
| MOTIF_SEAR_IN_PROT | 590-901 | 312 | | ||
| MOTIF_SEAR_IN_PROT | 596-892 | 297 | | ||
| PROSITE_SCAN | 608-619 | 12 | | ||
| PROSITE_SCAN | 683-694 | 12 | | ||
| PROSITE_SCAN | 821-832 | 12 | | ||
| SBASE | 590-895 | 306 | | ||
| TMPRED_SERVER | 845-895 | 51 | | ||
| TMPRED_SERVER | 854-904 | 51 | | ||
| UNIPROTKB | 782-892 | 111 | | ||
| UNIPROTKB | 590-736 | 147 | | ||
| UNIPROTKB | 662-676 | 15 | | ||
| UNIPROTKB | 836-862 | 27 | | ||
| UNIPROTKB | 782-892 | 111 | |
Sequence
. . . . . . G:649
atgcatggacctaaggcaacattgcaagacattgtattgcatttagagccccaaaatgaa C:60
M H G P K A T L Q D I V L H L E P Q N E P:20
. . . . . . G:709
attccggttgaccttctatgtcacgagcaattaagcgactcagaggaagaaaacgatgaa C:60
I P V D L L C H E Q L S D S E E E N D E P:20
. . . . . . G:769
atagatggagttaatcatcaacatttaccagcccgacgagccgaaccacaacgtcacaca C:60
I D G V N H Q H L P A R R A E P Q R H T P:20
. . . . . . G:829
atgttgtgtatgtgttgtaagtgtgaagccagaattgagctagtagtagaaagctcagca C:60
M L C M C C K C E A R I E L V V E S S A P:20
. . . . . . G:889
gacgaccttcgagcattccagcagctgtttctgaacaccctgtcctttgtgtgtccgtgg C:60
D D L R A F Q Q L F L N T L S F V C P W P:20
. G:907
tgtgcatcccagcagtaa C:18
C A S Q Q P:5