HPV58 E7

Accession: H000109

NC: LC270121.1

Uniprot: P26557

Protein: E7

Organism: Human papillomavirus type 58

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Mutation

574-600

601-700

701-800

801-870

Legend:same sensemissenseinsertiondeletion

Mutation type	Position	DESC	Disease	Reference
same sense	599	G → A	Disease: Cervical carcinoma Region : Southwest China	Ref
missense	632	C → T (T → I)	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	694	G → A	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	726	T → C	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	744	T → G	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
missense	760	G → A (G → S)	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	761	G → A	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	803	T → C	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref

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Domain&Motif

method	domain/motif name	position	length	description
CDD	E7	580-861	282	E7 protein, Early protein;
CDD	PHA02776	574-867	294	E7 protein; Provisional
CDD	PHA02624	634-744	111	large T antigen; Provisional
MOTIF_SCAN		784-795	12
MOTIF_SCAN		592-603	12
MOTIF_SCAN		664-675	12
MOTIF_SCAN		790-801	12
MOTIF_SCAN		580-597	18
MOTIF_SCAN		592-600	9
MOTIF_SCAN		766-774	9
MOTIF_SCAN		670-867	198
MOTIF_SCAN		580-861	282
MOTIF_SCAN		580-861	282
INTERPROSCAN		574-867	294
INTERPROSCAN		580-858	279
MOTIF_SEAR_IN_PROT		580-861	282
MOTIF_SEAR_IN_PROT		574-867	294
MOTIF_SEAR_IN_PROT		634-744	111
MOTIF_SEAR_IN_PROT		574-768	195
MOTIF_SEAR_IN_PROT		574-660	87
MOTIF_SEAR_IN_PROT		589-768	180
MOTIF_SEAR_IN_PROT		601-681	81
MOTIF_SEAR_IN_PROT		580-858	279
MOTIF_SEAR_IN_PROT		748-861	114
PROSITE_SCAN		580-597	18
PROSITE_SCAN		592-600	9
PROSITE_SCAN		592-603	12
PROSITE_SCAN		664-675	12
PROSITE_SCAN		766-774	9
PROSITE_SCAN		784-795	12
PROSITE_SCAN		790-801	12
SBASE		574-861	288
TMPRED_SERVER		727-780	54
TMPRED_SERVER		727-786	60
TMPRED_SERVER		814-867	54
UNIPROTKB		748-858	111
UNIPROTKB		637-651	15
UNIPROTKB		574-696	123
UNIPROTKB		802-828	27

Sequence

         .         .         .         .         .         .　　　　　G:633
atgagaggaaacaacccaacgctaagagaatatattttagatttacatcctgaaccaact　　　　　C:60
 M  R  G  N  N  P  T  L  R  E  Y  I  L  D  L  H  P  E  P  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:693
gacctattctgctatgagcaattatgtgacagctcagacgaggatgaaataggcttggac　　　　　C:60
 D  L  F  C  Y  E  Q  L  C  D  S  S  D  E  D  E  I  G  L  D 　　　　　P:20


         .         .         .         .         .         .　　　　　G:753
gggccagatggacaagcacaaccggccacagctaattactacattgtaacttgttgttac　　　　　C:60
 G  P  D  G  Q  A  Q  P  A  T  A  N  Y  Y  I  V  T  C  C  Y 　　　　　P:20


         .         .         .         .         .         .　　　　　G:813
acttgtggcaccacggttcgtttgtgtatcaacagtacaacaaccgacgtacgaacccta　　　　　C:60
 T  C  G  T  T  V  R  L  C  I  N  S  T  T  T  D  V  R  T  L 　　　　　P:20


         .         .         .         .         .          　　　　　G:870
cagcagctgcttatgggcacatgtaccattgtgtgccctagctgtgcacagcaataa   　　　　　C:57
 Q  Q  L  L  M  G  T  C  T  I  V  C  P  S  C  A  Q  Q       　　　　　P:18

Legend:gene mutationamino acid mutation

DETAIL

DOMAIN & MUTATION