HPV16 E7

Accession: H000091

NC: NP_041326.1

Uniprot: P03129

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Mutation

562-600

601-700

701-800

801-858

Legend:same sensemissenseinsertiondeletion

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Mutation type	Position	DESC	Disease	Reference
missense	528	A → T (K → E)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	579	T → A	Disease: Cervical carcinoma Region : Shandong	Ref
missense	580	A → C (T → P)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	581	C → A (T → K)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	585	G → A	Disease: Cervical carcinoma Region : Shandong	Ref
missense	585	G → T (L → F)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	586	C → G (H → D)	Disease: Cervical carcinoma Region : Shandong	Ref
deletion	590	A → C	Disease: Cervical carcinoma Region : Shandong	Ref
missense	590	A → G (A → S)	Disease: Cervical carcinoma	Ref
deletion	590	A → -	Disease: Cervical carcinoma Region : Shandong	Ref
missense	590	A → C (E → A)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	593	A → G (Y → C)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	596	T → A (M → K)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	597	G → A (M → K)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	598	T → A (L → I)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	600	A → G	Disease: Cervical carcinoma	Ref
missense	607	C → G (Q → E)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	608	A → G (Q → R)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	609	A → G (Q → E)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	623	A → G	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	625	C → T	Disease: Cervical carcinoma Region : Yunnan	Ref
missense	627	C → T (L → F)	Disease: Cervical carcinoma Region : Yunnan	Ref
missense	632	G → A (C → Y)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	635	A → G (Y → C)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	645	A → C (L → F)	Disease: Cervical carcinoma Region : Fujian	Ref
missense	645	A → C (N → S)	Disease: Cervical carcinoma Region : Henan	Ref
missense	646	A → C (N → H)	Disease: Cervical carcinoma Region : Yunnan	Ref
missense	646	A → C (H → N)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	646	A → C	Disease: Squamous carcinoma,Cervical carcinoma Region : Jiangxi, Sichuan	Ref
missense	647	A → G (N → S)	hot spot Disease: Cervical carcinoma Region : Xinjiang, Fujian, Southwest China, Yunnan, Hubei Nation : Uygur,Han	Ref
missense	647	A → G (N → D)	hot spot Disease: Cervical carcinoma Region : Southwest China, Sichuan	Ref
missense	647	A → G (S → N)	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	647	A → G (L → F)	hot spot Disease: Cervical carcinoma Region : Xinjiang, Fujian, Henan, Southwest China Nation : Uygur,Han	Ref
missense	647	T → C (N → S)	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	647	A → G (D → S)	Disease: Cervical carcinoma Region : Hubei, Xinjiang Nation : Uygur,Han	Ref
missense	658	G → A (K → E)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	663	G → A	Disease: Cervical carcinoma Region : Xinjiang, Sichuan Nation : Uygur,Han	Ref
same sense	666	G → A	hot spot Disease: Cervical carcinoma Region : Sichuan, Fujian, Henan, Southwest China, Yunnan, Beijing, Zhejiang	Ref
same sense	666	C → T	Disease: Cervical carcinoma Region : Guangdong	Ref
same sense	675	A → G	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	676	G → A (N → D)	Disease: Cervical carcinoma Region : Beijing	Ref
missense	697	G → A (K → E)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	700	C → T	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	712	C → A/T	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	712	C → A	Disease: Cervical carcinoma Region : Hubei	Ref
missense	731	T → C (F → S)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	732	T → C	Disease: Cervical carcinoma Region : Southwest China	Ref
missense	748	T → G (S → A)	Disease: Cervical carcinoma Region : Yunnan	Ref
missense	749	C → T (S → F)	Disease: Cervical carcinoma Region : Yunnan	Ref
same sense	756	T → G	Disease: Cervical carcinoma Region : Zhejiang	Ref
same sense	758	G → A	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	760	T → C	Disease: Cervical carcinoma Region : Henan, Beijing	Ref
missense	761	T → C (L → S)	Disease: Cervical carcinoma	Ref
same sense	789	T → C	hot spot Disease: Cervical carcinoma Region : Henan, Southwest China	Ref
missense	790	C → T (R → C)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	795	T → G	Disease: Cervical carcinoma Region : Southwest China	Ref
missense	812	T → C (M → T)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	822	A → G	Disease: Cervical carcinoma Region : Hubei	Ref
same sense	823	G → A	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	835	C → A (P → T)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	843	T → C	hot spot Disease: Cervical carcinoma Region : Southwest China, Sichuan, Fujian, Henan, Beijing, Zhejiang	Ref
same sense	844	A → C	Disease: Cervical carcinoma Region : Guangdong	Ref
same sense	845	T → C	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur	Ref
same sense	846	T → C	hot spot Disease: Cervical carcinoma Region : Southwest China, Sichuan, Xinjiang, Fujian, Henan, Yunnan, Beijing, Hubei, Zhejiang Nation : Uygur,Han	Ref
same sense	846	A → G	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	849	G → A (N → D)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	897	G → C	Disease: Cervical carcinoma Region : Beijing	Ref

Domain&Motif

method	domain/motif name	position	length	description
CDD	E7	568-846	279	E7 protein, Early protein;
CDD	PHA02776	562-852	291	E7 protein; Provisional
MOTIF_SCAN		646-657	12
MOTIF_SCAN		580-591	12
MOTIF_SCAN		652-663	12
MOTIF_SCAN		775-786	12
MOTIF_SCAN		793-804	12
MOTIF_SCAN		751-759	9
MOTIF_SCAN		844-852	9
MOTIF_SCAN		568-846	279
MOTIF_SCAN		568-846	279
INTERPROSCAN		562-855	294
INTERPROSCAN		568-843	276
MOTIF_SEAR_IN_PROT		568-846	279
MOTIF_SEAR_IN_PROT		562-852	291
MOTIF_SEAR_IN_PROT		565-633	69
MOTIF_SEAR_IN_PROT		574-702	129
MOTIF_SEAR_IN_PROT		622-705	84
MOTIF_SEAR_IN_PROT		598-714	117
MOTIF_SEAR_IN_PROT		568-843	276
PROSITE_SCAN		580-591	12
PROSITE_SCAN		646-657	12
PROSITE_SCAN		652-663	12
PROSITE_SCAN		751-759	9
PROSITE_SCAN		775-786	12
PROSITE_SCAN		793-804	12
PROSITE_SCAN		844-852	9
SBASE		562-846	285
TMPRED_SERVER		790-846	57
TMPRED_SERVER		796-846	51
UNIPROTKB		733-843	111
UNIPROTKB		625-639	15
UNIPROTKB		787-813	27
UNIPROTKB		562-681	120

Sequence

         .         .         .         .         .         .　　　　　G:621
atgcatggagatacacctacattgcatgaatatatgttagatttgcaaccagagacaact　　　　　C:60
 M  H  G  D  T  P  T  L  H  E  Y  M  L  D  L  Q  P  E  T  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:681
gatctctactgttatgagcaattaaatgacagctcagaggaggaggatgaaatagatggt　　　　　C:60
 D  L  Y  C  Y  E  Q  L  N  D  S  S  E  E  E  D  E  I  D  G 　　　　　P:20


         .         .         .         .         .         .　　　　　G:741
ccagctggacaagcagaaccggacagagcccattacaatattgtaaccttttgttgcaag　　　　　C:60
 P  A  G  Q  A  E  P  D  R  A  H  Y  N  I  V  T  F  C  C  K 　　　　　P:20


         .         .         .         .         .         .　　　　　G:801
tgtgactctacgcttcggttgtgcgtacaaagcacacacgtagacattcgtactttggaa　　　　　C:60
 C  D  S  T  L  R  L  C  V  Q  S  T  H  V  D  I  R  T  L  E 　　　　　P:20


         .         .         .         .         .          　　　　　G:858
gacctgttaatgggcacactaggaattgtgtgccccatctgttctcagaaaccataa   　　　　　C:57
 D  L  L  M  G  T  L  G  I  V  C  P  I  C  S  Q  K  P       　　　　　P:18

Legend:gene mutationamino acid mutation

DETAIL

DOMAIN & MUTATION