HPV58 E6

Accession: H000086

NC: AEI61670.1

Uniprot: P26555

Protein: E6

Organism: Human papillomavirus type 58

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

110-200

201-300

301-400

401-500

501-559

Legend:same sensemissenseinsertiondeletion

Mutation type	Position	DESC	Disease	Reference
same sense	187	C → T	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	259	A → G	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	260	A → C	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	307	C → T	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref
missense	388	A → C (K → N)	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	388	A → C	hot spot Disease: Cervical carcinoma Region : Southwest China	Ref

show more details

Domain&Motif

method	domain/motif name	position	length	description
CDD	E6	197-526	330	Early Protein (E6);
CDD	PHA02779	137-532	396	E6 protein; Provisional
CDD	PHA02775	134-526	393	E6; Provisional
MOTIF_SCAN		347-358	12
MOTIF_SCAN		488-499	12
MOTIF_SCAN		539-550	12
MOTIF_SCAN		140-151	12
MOTIF_SCAN		173-184	12
MOTIF_SCAN		278-295	18
MOTIF_SCAN		380-388	9
MOTIF_SCAN		494-502	9
MOTIF_SCAN		506-514	9
MOTIF_SCAN		323-346	24
MOTIF_SCAN		197-526	330
MOTIF_SCAN		197-526	330
INTERPROSCAN		197-526	330
MOTIF_SEAR_IN_PROT		197-526	330
MOTIF_SEAR_IN_PROT		137-532	396
MOTIF_SEAR_IN_PROT		134-526	393
MOTIF_SEAR_IN_PROT		413-526	114
MOTIF_SEAR_IN_PROT		131-232	102
MOTIF_SEAR_IN_PROT		197-526	330
MOTIF_SEAR_IN_PROT		113-325	213
MOTIF_SEAR_IN_PROT		152-238	87
MOTIF_SEAR_IN_PROT		278-319	42
PROSITE_SCAN		140-151	12
PROSITE_SCAN		173-184	12
PROSITE_SCAN		278-295	18
PROSITE_SCAN		323-346	24
PROSITE_SCAN		347-358	12
PROSITE_SCAN		380-388	9
PROSITE_SCAN		488-499	12
PROSITE_SCAN		494-502	9
PROSITE_SCAN		506-514	9
PROSITE_SCAN		539-550	12
SBASE		113-169	57
SBASE		197-526	330
RADAR		296-343	48
RADAR		416-463	48
UNIPROTKB		197-307	111
UNIPROTKB		416-526	111

Sequence

         .         .         .         .         .         .　　　　　G:169
atgttccaggacgcagaggagaaaccacggacattgcatgatttgtgtcaggcgttggag　　　　　C:60
 M  F  Q  D  A  E  E  K  P  R  T  L  H  D  L  C  Q  A  L  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:229
acatctgtgcatgaaatcgaattgaaatgcgttgaatgcaaaaagactttgcagcgatct　　　　　C:60
 T  S  V  H  E  I  E  L  K  C  V  E  C  K  K  T  L  Q  R  S 　　　　　P:20


         .         .         .         .         .         .　　　　　G:289
gaggtatatgactttgtatttgcagatttaagaatagtgtatagagatggaaatccattt　　　　　C:60
 E  V  Y  D  F  V  F  A  D  L  R  I  V  Y  R  D  G  N  P  F 　　　　　P:20


         .         .         .         .         .         .　　　　　G:349
gcagtatgtaaagtgtgcttacgattgctatctaaaataagtgagtatagacattataat　　　　　C:60
 A  V  C  K  V  C  L  R  L  L  S  K  I  S  E  Y  R  H  Y  N 　　　　　P:20


         .         .         .         .         .         .　　　　　G:409
tattcgctatatggagacacattagaacaaacactaaaaaagtgtttaaatgaaatatta　　　　　C:60
 Y  S  L  Y  G  D  T  L  E  Q  T  L  K  K  C  L  N  E  I  L 　　　　　P:20


         .         .         .         .         .         .　　　　　G:469
attagatgtattatttgtcaaagaccattgtgtccacaagaaaaaaaaaggcatgtggat　　　　　C:60
 I  R  C  I  I  C  Q  R  P  L  C  P  Q  E  K  K  R  H  V  D 　　　　　P:20


         .         .         .         .         .         .　　　　　G:529
ttaaacaaaaggtttcataatatttcgggtcgttggacagggcgctgtgcagtgtgttgg　　　　　C:60
 L  N  K  R  F  H  N  I  S  G  R  W  T  G  R  C  A  V  C  W 　　　　　P:20


         .         .         .                              　　　　　G:559
agaccccgacgtagacaaacacaagtgtaa                              　　　　　C:30
 R  P  R  R  R  Q  T  Q  V                                  　　　　　P:9

Legend:gene mutationamino acid mutation

DETAIL

DOMAIN & MUTATION