HPV45 E6

Accession: H000080

NC: ABP99808.1

Uniprot: P21735

Protein: E6

Organism: Human papillomavirus type 45

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

102-200

201-300

301-400

401-500

501-578

Legend:same sensemissenseinsertiondeletion

Mutation type	Position	DESC	Disease	Reference
same sense	134	C → T	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	157	C → T (T → I)	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	259	G → T (C → F)	hot spot Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	341	T → C	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	482	T → C	hot spot Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	497	A → G	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	549	C → A	Disease: Cervical carcinoma Region : Sichuan	Ref

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Domain&Motif

method	domain/motif name	position	length	description
CDD	E6	195-524	330	Early Protein (E6);
CDD	PHA02779	141-524	384	E6 protein; Provisional
CDD	PHA02775	132-524	393	E6; Provisional
MOTIF_SCAN		165-176	12
MOTIF_SCAN		558-569	12
MOTIF_SCAN		171-182	12
MOTIF_SCAN		381-392	12
MOTIF_SCAN		519-530	12
MOTIF_SCAN		495-512	18
MOTIF_SCAN		321-344	24
MOTIF_SCAN		195-524	330
MOTIF_SCAN		195-524	330
INTERPROSCAN		195-524	330
MOTIF_SEAR_IN_PROT		195-524	330
MOTIF_SEAR_IN_PROT		141-524	384
MOTIF_SEAR_IN_PROT		132-524	393
MOTIF_SEAR_IN_PROT		300-395	96
MOTIF_SEAR_IN_PROT		351-518	168
MOTIF_SEAR_IN_PROT		195-524	330
PROSITE_SCAN		165-176	12
PROSITE_SCAN		171-182	12
PROSITE_SCAN		321-344	24
PROSITE_SCAN		381-392	12
PROSITE_SCAN		495-512	18
PROSITE_SCAN		519-530	12
PROSITE_SCAN		558-569	12
SBASE		195-524	330
RADAR		267-338	72
RADAR		396-467	72
UNIPROTKB		195-305	111
UNIPROTKB		414-524	111

Sequence

         .         .         .         .         .         .　　　　　G:161
atggcgcgctttgacgatccaaagcaacgaccctacaagctaccagatttgtgcacagaa　　　　　C:60
 M  A  R  F  D  D  P  K  Q  R  P  Y  K  L  P  D  L  C  T  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:221
ttgaatacatcactacaagacgtatctattgcctgtgtatattgcaaagcaacattggaa　　　　　C:60
 L  N  T  S  L  Q  D  V  S  I  A  C  V  Y  C  K  A  T  L  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:281
cgcacagaggtatatcaatttgcttttaaagatttatgtatagtgtatagagactgtata　　　　　C:60
 R  T  E  V  Y  Q  F  A  F  K  D  L  C  I  V  Y  R  D  C  I 　　　　　P:20


         .         .         .         .         .         .　　　　　G:341
gcatatgctgcatgccataaatgtatagacttttattccagaattagagaattaagatat　　　　　C:60
 A  Y  A  A  C  H  K  C  I  D  F  Y  S  R  I  R  E  L  R  Y 　　　　　P:20


         .         .         .         .         .         .　　　　　G:401
tattcaaactctgtatatggagagacactggaaaaaataactaatacagagttgtataat　　　　　C:60
 Y  S  N  S  V  Y  G  E  T  L  E  K  I  T  N  T  E  L  Y  N 　　　　　P:20


         .         .         .         .         .         .　　　　　G:461
ttgttaataaggtgcctgcggtgccagaaaccattgaacccagcagaaaaacgtagacac　　　　　C:60
 L  L  I  R  C  L  R  C  Q  K  P  L  N  P  A  E  K  R  R  H 　　　　　P:20


         .         .         .         .         .         .　　　　　G:521
cttaaggacaaacgaagatttcacagcatagctggacagtaccgagggcagtgtaataca　　　　　C:60
 L  K  D  K  R  R  F  H  S  I  A  G  Q  Y  R  G  Q  C  N  T 　　　　　P:20


         .         .         .         .         .          　　　　　G:578
tgttgtgaccaggcacggcaagaaagacttcgcagacgtagggaaacacaagtatag   　　　　　C:57
 C  C  D  Q  A  R  Q  E  R  L  R  R  R  R  E  T  Q  V       　　　　　P:18

Legend:gene mutationamino acid mutation

DETAIL

DOMAIN & MUTATION