HPV16 E6

Accession: H000069

NC: NP_041325.1

Uniprot: P03126

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

83-100

101-200

201-300

301-400

401-500

501-559

Legend:same sensemissenseinsertiondeletion

show more details

Mutation type	Position	DESC	Disease	Reference
same sense	94	G → A	Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Beijing	Ref
same sense	94	T → C (R → G)	Disease: Cervical carcinoma Region : Guangdong	Ref
same sense	95	G → A	Disease: Cervical carcinoma	Ref
same sense	95	C → T (R → G)	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	107	T → C	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	109	T → C	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	110	A → G	Disease: Esophageal cancer Region : Xinjiang Nation : Uygur,Han,Kazak	Ref
missense	131	A → G (R → G)	Disease: Cervical carcinoma Region : Zhejiang	Ref
missense	131	G → A (G → R)	Disease: Cervical carcinoma Region : Southwest China, Sichuan	Ref
same sense	131	A → C	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Fujian, Henan	Ref
same sense	131	T → G	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	133	A → G/C (/G → S)	Disease: Cervical carcinoma Region : Shandong, Xinjiang Nation : Uygur,Han	Ref
missense	135	A → C (D → E)	Disease: Esophageal cancer Region : Xinjiang Nation : Uygur,Kazak	Ref
missense	135	A → C (K → T)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur	Ref
same sense	136	G → C	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	137	A → G	Disease: Cervical carcinoma Region : Neimenggu, Jilin	Ref
same sense	142	A → G	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	145	G → T	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	146	G → A	Disease: Cervical carcinoma Region : Henan	Ref
same sense	159	T → A	Disease: Cervical carcinoma Region : Beijing	Ref
missense	162	A → C (Q → P)	Disease: Cervical carcinoma Region : Fujian	Ref
missense	162	A → T (Q → L)	Disease: Adenosquamous carcinoma Region : Shandong	Ref
missense	164	A → T (T → S)	Disease: Cervical carcinoma Region : Fujian	Ref
missense	165	C → T (T → I)	Disease: Cervical carcinoma Region : Fujian	Ref
missense	168	C → G (T → S)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Xinjiang, Zhejiang Nation : Uygur,Han	Ref
same sense	173	C → T	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Sichuan	Ref
missense	173	G → A (H → Y)	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	176	G → A (D → E)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Shandong, Yunnan	Ref
missense	176	G → A (N → D)	Disease: Cervical carcinoma Region : Shandong, Zhejiang, Neimenggu, Jilin, Beijing	Ref
missense	176	G → A (D → N)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Shandong	Ref
missense	178	T → G/A (D → E/-)	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Xinjiang, Southwest China, Henan, Beijing, Zhejiang, Yunnan Nation : Uygur,Han	Ref
missense	178	T → C (D → E)	Disease: Cervical carcinoma Region : Hubei	Ref
same sense	178	T → G	hot spot Disease: Cervical carcinoma Region : Xinjiang, Shandong, Zhejiang, Southwest China Nation : Uygur,Han	Ref
missense	178	A → C (D → E)	hot spot Disease: Cervical carcinoma Region : Guangdong	Ref
missense	178	A → G (D → E)	Disease: Cervical carcinoma Region : Tianjin, Shandong	Ref
same sense	178	T → A	Disease: Cervical carcinoma Region : Shandong Laiwu	Ref
missense	185	T → G (L → V)	Disease: Cervical carcinoma Region : Fujian, Sichuan	Ref
missense	188	G → T (L → I)	Disease: Cervical carcinoma Region : Tianjin	Ref
same sense	188	G → C	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin	Ref
same sense	193	T → C	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	194	G → A	Disease: Cervical carcinoma Region : Neimenggu, Jilin	Ref
same sense	203	A → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Sichuan	Ref
same sense	240	C → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Sichuan	Ref
same sense	241	T → G	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Zhejiang, Fujian, Henan, Beijing, Tianjin	Ref
missense	256	T → C	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	256	G → T (E → D)	Disease: Cervical carcinoma Region : Shandong	Ref
missense	267	G → A (R → K)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Shandong	Ref
missense	276	A → G	Disease: Cervical carcinoma Region : Shandong, Sichuan, Zhejiang	Ref
missense	276	A → G (N → S)	Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Henan, Southwest China, Yunnan	Ref
missense	276	A → G (D → S)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Southwest China	Ref
missense	278	C → T (P → S)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	278	T → G/A	Disease: Cervical carcinoma Region : Neimenggu, Jilin	Ref
same sense	286	T → G	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	289	A → G	Disease: Cervical carcinoma Region : Southwest China	Ref
missense	295	T → G (D → E)	Disease: Cervical carcinoma,Esophageal cancer Region : Sichuan, Neimenggu, Jilin, Xinjiang Nation : Uygur,Han,Kazak	Ref
missense	296	T → G (E → D)	Disease: Cervical carcinoma Region : Zhejiang, Beijing, Shandong	Ref
missense	298	A → C (K → N)	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	306	A → C	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	310	T → C	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	310	T → G (F → L)	Disease: Esophageal cancer,Cervical carcinoma Region : Xinjiang Nation : Uygur,Kazak	Ref
same sense	315	C → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin	Ref
missense	320	A → G (I → V)	Disease: Cervical carcinoma Region : Southwest China, Sichuan	Ref
same sense	321	T → C	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	335	C → T/G (N → S)	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Southwest China, Zhejiang	Ref
missense	335	C → T/G (H → Y)	hot spot Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Shandong, Sichuan, Southwest China, Zhejiang	Ref
missense	341	T → G (C → G)	Disease: Cervical carcinoma Region : Henan	Ref
missense	341	T → C (C → L)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	350	G → T (V → L)	Disease: Cervical carcinoma Region : Southwest China	Ref
missense	350	T → G (L → V)	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Xinjiang, Zhejiang, Yunnan, Beijing Nation : Uygur,Han	Ref
missense	375	A → G (Q → R)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	375	A → G	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
missense	385	A → C (K → N)	Disease: Cervical carcinoma Region : Guangdong	Ref
missense	387	C → T (P → L)	Disease: Cervical carcinoma	Ref
missense	393	G → T (C → F)	Disease: Cervical carcinoma Region : Zhejiang	Ref
same sense	395	T → G	Disease: Cervical carcinoma Region : Neimenggu, Jilin	Ref
missense	410	T → A (C → S)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	430	A → G	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
deletion	440	G → -	Disease: Adenosquamous carcinoma Region : Shandong	Ref
missense	442	A → C (E → D)	hot spot Disease: Adenosquamous carcinoma,Cervical carcinoma Region : Shandong, Sichuan, Neimenggu, Jilin, Henan, Zhejiang, Beijing	Ref
missense	443	G → A (K → E)	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	443	G → A	Disease: Cervical carcinoma Region : Shandong	Ref
same sense	450	T → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin	Ref
same sense	459	T → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin	Ref
same sense	464	A → G	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Sichuan	Ref
same sense	484	T → C	Disease: Cervical carcinoma	Ref
same sense	487	A → G	Disease: Adenosquamous carcinoma Region : Shandong	Ref
missense	487	A → G (I → M)	Disease: Cervical carcinoma	Ref
same sense	489	G → A	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	499	G → T (W → T)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	508	A → C	Disease: Cervical carcinoma Region : Zhejiang	Ref
same sense	511	T → C	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Sichuan	Ref
missense	516	C → G (S → C)	Disease: Cervical carcinoma Region : Sichuan, Neimenggu, Jilin, Fujian	Ref
missense	525	G → A (K → R)	Disease: Cervical carcinoma Region : Zhejiang, Beijing, Shandong	Ref
missense	525	G → A (R → K)	Disease: Adenosquamous carcinoma Region : Shandong	Ref
same sense	532	A → G	Disease: Cervical carcinoma Region : Southwest China	Ref
same sense	533	A → T	Disease: Adenosquamous carcinoma Region : Shandong	Ref
same sense	538	A → T	Disease: Cervical carcinoma	Ref
missense	543	G → A (L → F)	Disease: Cervical carcinoma Region : Tianjin	Ref
missense	548	A → G (T → A)	Disease: Cervical carcinoma Region : Xinjiang Nation : Uygur,Han	Ref
same sense	559	T → G	Disease: Cervical carcinoma Region : Neimenggu, Jilin	Ref
missense	617	T → A (S → T)	Disease: Cervical carcinoma Region : Fujian	Ref

Domain&Motif

method	domain/motif name	position	length	description
CDD	E6	191-505	315	Early Protein(E6)
CDD	PHA02779	131-505	375	E6 protein; Provisional
CDD	PHA02775	128-505	378	E6;Provisional
MOTIF_SCAN		539-550	12
MOTIF_SCAN		167-178	12
MOTIF_SCAN		359-370	12
MOTIF_SCAN		536-547	12
MOTIF_SCAN		272-289	18
MOTIF_SCAN		500-508	9
MOTIF_SCAN		527-535	9
MOTIF_SCAN		536-544	9
MOTIF_SCAN		317-340	24
MOTIF_SCAN		404-556	153
MOTIF_SCAN		92-136	45
MOTIF_SCAN		191-520	330
MOTIF_SCAN		191-520	330
INTERPROSCAN		191-520	330
MOTIF_SEAR_IN_PROT		191-520	330
MOTIF_SEAR_IN_PROT		131-520	390
MOTIF_SEAR_IN_PROT		128-520	393
MOTIF_SEAR_IN_PROT		203-280	78
MOTIF_SEAR_IN_PROT		191-520	330
PROSITE_SCAN		167-178	12
PROSITE_SCAN		272-289	18
PROSITE_SCAN		317-340	24
PROSITE_SCAN		359-370	12
PROSITE_SCAN		500-508	9
PROSITE_SCAN		527-535	9
PROSITE_SCAN		536-544	9
PROSITE_SCAN		536-547	12
PROSITE_SCAN		539-550	12
SBASE		89-184	96
SBASE		191-505	315
UNIPROTKB		191-301	111
UNIPROTKB		410-520	111
UNIPROTKB		545-556	12

Sequence

         .         .         .         .         .         .　　　　　G:142
atgcaccaaaagagaactgcaatgtttcaggacccacaggagcgacccagaaagttacca　　　　　C:60
 M  H  Q  K  R  T  A  M  F  Q  D  P  Q  E  R  P  R  K  L  P 　　　　　P:20


         .         .         .         .         .         .　　　　　G:202
cagttatgcacagagctgcaaacaactatacatgatataatattagaatgtgtgtactgc　　　　　C:60
 Q  L  C  T  E  L  Q  T  T  I  H  D  I  I  L  E  C  V  Y  C 　　　　　P:20


         .         .         .         .         .         .　　　　　G:262
aagcaacagttactgcgacgtgaggtatatgactttgcttttcgggatttatgcatagta　　　　　C:60
 K  Q  Q  L  L  R  R  E  V  Y  D  F  A  F  R  D  L  C  I  V 　　　　　P:20


         .         .         .         .         .         .　　　　　G:322
tatagagatgggaatccatatgctgtatgtgataaatgtttaaagttttattctaaaatt　　　　　C:60
 Y  R  D  G  N  P  Y  A  V  C  D  K  C  L  K  F  Y  S  K  I 　　　　　P:20


         .         .         .         .         .         .　　　　　G:382
agtgagtatagacattattgttatagtttgtatggaacaacattagaacagcaatacaac　　　　　C:60
 S  E  Y  R  H  Y  C  Y  S  L  Y  G  T  T  L  E  Q  Q  Y  N 　　　　　P:20


         .         .         .         .         .         .　　　　　G:442
aaaccgttgtgtgatttgttaattaggtgtattaactgtcaaaagccactGtgtcctgaa　　　　　C:60
 K  P  L  C  D  L  L  I  R  C  I  N  C  Q  K  P  L  C  P  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:502
gaaaagcaaagacatctggacaaaaagcaaagattccataatataaggggtcggtggacc　　　　　C:60
 E  K  Q  R  H  L  D  K  K  Q  R  F  H  N  I  R  G  R  W  T 　　　　　P:20


         .         .         .         .         .          　　　　　G:559
ggtcgatgtatgtcttgttgcagatcatcaagaacacgtagagaaacccagctgtaa   　　　　　C:57
 G  R  C  M  S  C  C  R  S  S  R  T  R  R  E  T  Q  L       　　　　　P:18

Legend:gene mutationamino acid mutation

Structure&Mutation

559

Legend:HelixTurnBeta strand

Mutation

Feature key	Position(s)	Length
Turn	116-124	9
Helix	137-157	21
Turn	170-178	9
Turn	194-202	9
Helix	218-244	27
Beta strand	260-268	9
Beta strand	275-286	12
Helix	293-337	45
Beta strand	338-352	15
Helix	356-379	24
Helix	389-397	9
Beta strand	404-412	9
Turn	413-421	9
Helix	437-463	27
Beta strand	476-487	12
Beta strand	494-505	12
Turn	515-523	9
Beta strand	545-556	12

DETAIL

DOMAIN & MUTATION

HPV16 E6

Accession: H000069

NC: NP_041325.1

Uniprot: P03126

Protein: E6

Organism: Human papillomavirus type 16

Function

Mutation

Domain&Motif

Sequence

Structure&Mutation