HPV16 E4

Accession: H000047

NC: NP_041329.1

Uniprot: P06922

Protein: E4

Organism: Human papillomavirus type 16

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Domain&Motif

method	domain/motif name	position	length	description
CDD	Pap_E4	3341-3613	273	E4 protein; This is is a family of Papillomavirus proteins, E4, coded for by ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known.
CDD	PHA03417	3332-3613	282	E4 protein; Provisional
MOTIF_SCAN		3458-3469	12
MOTIF_SCAN		3470-3481	12
MOTIF_SCAN		3332-3340	9
MOTIF_SCAN		3341-3616	276
MOTIF_SCAN		3461-3487	27
MOTIF_SCAN		3341-3616	276
INTERPROSCAN		3341-3613	273
MOTIF_SEAR_IN_PROT		3341-3613	273
MOTIF_SEAR_IN_PROT		3332-3613	282
MOTIF_SEAR_IN_PROT		3356-3613	258
MOTIF_SEAR_IN_PROT		3401-3514	114
MOTIF_SEAR_IN_PROT		3371-3475	105
MOTIF_SEAR_IN_PROT		3341-3613	273
PROSITE_SCAN		3458-3469	12
PROSITE_SCAN		3470-3481	12
SBASE		3341-3616	276
UNIPROTKB		3389-3475	87
UNIPROTKB		3365-3376	12

Sequence

         .         .         .         .         .         .　　　　　G:3391
tattatgtcctacatctgtgtttagcagcaacgaagtatcctctcctgaaattattaggc　　　　　C:60
 Y  Y  V  L  H  L  C  L  A  A  T  K  Y  P  L  L  K  L  L  G 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3451
agcacttggccaaccaccccgccgcgacccataccaaagccgtcgccttgggcaccgaag　　　　　C:60
 S  T  W  P  T  T  P  P  R  P  I  P  K  P  S  P  W  A  P  K 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3511
aaacacagacgactatccagcgaccaagatcagagccagacaccggaaacccctgccaca　　　　　C:60
 K  H  R  R  L  S  S  D  Q  D  Q  S  Q  T  P  E  T  P  A  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:3571
ccactaagttgttgcacagagactcagtggacagtgctccaatcctcactgcatttaaca　　　　　C:60
 P  L  S  C  C  T  E  T  Q  W  T  V  L  Q  S  S  L  H  L  T 　　　　　P:20


         .         .         .         .                    　　　　　G:3619
gctcacacaaaggacggattaactgtaatagtaacactacacccatag            　　　　　C:48
 A  H  T  K  D  G  L  T  V  I  V  T  L  H  P                　　　　　P:15

DETAIL

DOMAIN & MUTATION