HPV60 E6
Accession: H003391
NC: NP_043437.1
Protein: E6
Organism: Human papillomavirus type 60
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGCAGATGGAAGAAGACAGGTTTCCAACAACAGTGGCTGATTATTGCTCTGAATTTGAT C:60
M Q M E E D R F P T T V A D Y C S E F D P:20
. . . . . . G:221
ATTCCTTTAAAAGATCTTAAGTTAAAATGTGTATTTTGTAGATTTTACTTAACTGAACAG C:60
I P L K D L K L K C V F C R F Y L T E Q P:20
. . . . . . G:281
CAGTTGGCTGCATTTTATATTAAGAATTTAAAGTTAGTTTGGAAAAACCGTTATTGCTTT C:60
Q L A A F Y I K N L K L V W K N R Y C F P:20
. . . . . . G:341
GCTTGTTGTACTCCGTGTCTTAGACTTACTGCTAAATTTGAAGCTGAAAACTATTTTCAG C:60
A C C T P C L R L T A K F E A E N Y F Q P:20
. . . . . . G:401
TGTATGTGTAAAGGAGAAGTATTAGAAGTTCTAACTCGTATTCCTTTGAGTTCTCTTTCT C:60
C M C K G E V L E V L T R I P L S S L S P:20
. . . . . . G:461
GTACGCTGTTTTGATTGCCTTACATTGTTATCTTTTGCAGAAAAAATAGATTGTATAATT C:60
V R C F D C L T L L S F A E K I D C I I P:20
. . . . . . G:521
AGTGGTCAAAACTTTTATCTTGTAAGGGGTCGCTGGAGATCATATTGTAGAAATTGCATT C:60
S G Q N F Y L V R G R W R S Y C R N C I P:20
G:530
GAGAAATGA C:9
E K P:2