HPV48 E6
Accession: H003389
NC: NP_043416.1
Protein: E6
Organism: Human papillomavirus type 48
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGAGCCACAATTTCCTACTGATTTGGATTCATACTGCAAATATTTTAACATAAGCTTT C:60
M E P Q F P T D L D S Y C K Y F N I S F P:20
. . . . . . G:221
TTTGACTTAGTTCTTAAGTGTATCTTTTGTAAATTTTCTGTATCTATTGTTGATCTTGCT C:60
F D L V L K C I F C K F S V S I V D L A P:20
. . . . . . G:281
TCTTTTCATAACAAACGACTGTCTGTAATTTGGAGAGATAATACACCATTTGCATGTTGT C:60
S F H N K R L S V I W R D N T P F A C C P:20
. . . . . . G:341
ACTAAATGTTTAAGATTAACTGCATTATATGAAAAAGATAATTTTTTTGTCTGTACTGCA C:60
T K C L R L T A L Y E K D N F F V C T A P:20
. . . . . . G:401
AAAAGTCATTTGTTAACTGGTTTAGTTAAAAAGGAATTGTCAGATATTAATATTAGGTGC C:60
K S H L L T G L V K K E L S D I N I R C P:20
. . . . . . G:461
CAACATTGTTATTCATTTTTAGATTATTTAGAAAAGTTGTACCATTTATATAATGATGTT C:60
Q H C Y S F L D Y L E K L Y H L Y N D V P:20
. . . . . . G:521
GATTTTCTGTTAATTCGCGGGACTTGGAGAGGTGTTTGTAGAAATTGTATCAGCCATGAG C:60
D F L L I R G T W R G V C R N C I S H E P:20
G:530
GGGAGATAA C:9
G R P:2