HPV50 E6
Accession: H003388
NC: NP_043423.1
Protein: E6
Organism: Human papillomavirus type 50
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGAGCCTCAGAGAGCTAAAAATTTGGTGGACTATTGCAAGCAACAACAGATTAGTTTT C:60
M E P Q R A K N L V D Y C K Q Q Q I S F P:20
. . . . . . G:221
TTTGAATTAGAGCTACAGTGCTTGTTTTGTAAATTTGTTATTACTTTGCCTGACTTAGCT C:60
F E L E L Q C L F C K F V I T L P D L A P:20
. . . . . . G:281
AGCTTTCATTGTAAAAAGTTAGCTCTTGTTTATAGAGATGGTATTGCTTTTGCTGCGTGC C:60
S F H C K K L A L V Y R D G I A F A A C P:20
. . . . . . G:341
GCTAAATGCTTAAGATTGTCTGCTATCTTTGAAAATGAGAGATATTATACTTGCTCTATA C:60
A K C L R L S A I F E N E R Y Y T C S I P:20
. . . . . . G:401
AAAGCTTACTTGCTATCTGATTTGATTGGTAGACCTTTGAGTGAAATCGCAATTCGCTGT C:60
K A Y L L S D L I G R P L S E I A I R C P:20
. . . . . . G:461
GAAAATTGTATGTGTTTGTTGGATTATATTGAAAAGTACGATTGTATTTGTCACGGTGGT C:60
E N C M C L L D Y I E K Y D C I C H G G P:20
. . . . . . G:521
TATTTTCATTTAGTTAGAGGTAATTGGAGGGGCTGTTGTAGAAATTGTTACGAACATGAG C:60
Y F H L V R G N W R G C C R N C Y E H E P:20
G:527
GGGTGA C:6
G P:1