HPV20 E6

Accession: H003384

NC: AAA79387.1

Protein: E6

Organism: Human papillomavirus type 20

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MATPPSSEDS DEGPSNIGE KPPILEPPL ATICGLAKL EIPLDDCLI CNFCGNFLT
         .         .         .         .         .         .
HLEVCEFDEK LTLIWKDHL FACCRVCCS TATYEFNQF ESTVLGRDI QVTGKSVFD
         .         .         .         .                    
IDVRCYTCMK LDSIEKLDI GRKRPFYLV GSWKGICRL KHFQ