HPV121 E6
Accession: H003379
NC: YP_003668025.1
Protein: E6
Organism: Human papillomavirus type 12
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGACTTGCAGCAATCACCTACTCCTGTAACTATTACCGAGTATTGTAACACCTTTGGC C:60
M D L Q Q S P T P V T I T E Y C N T F G P:20
. . . . . . G:
TTTTCTTTAAAGGACATTAGACTACCTTGTACCTTTTGTCGCTTTTATTTAACAATTCAG C:60
F S L K D I R L P C T F C R F Y L T I Q P:20
. . . . . . G:
GATCTTGCATCGTTTGAACTAAAACAATTTAGGTTATTATGGAAAGGACCATTTTGTTAT C:60
D L A S F E L K Q F R L L W K G P F C Y P:20
. . . . . . G:
GCGTGTTGTAGAAGTTGTATGAGATTAACAGCTGCCTTTGAAGTTCGAAAACATTATCAA C:60
A C C R S C M R L T A A F E V R K H Y Q P:20
. . . . . . G:
TGTTCCTGCTCTTGCCTGTTTTTGGAAGATTTGTTGGGAAGACCTTTACAGCATATTCCT C:60
C S C S C L F L E D L L G R P L Q H I P P:20
. . . . . . G:
ATGAGATGTTTACTATGTTTAGCTTTGTTAGATTATGCTGAAAAGCTTCAGCATTTCTGT C:60
M R C L L C L A L L D Y A E K L Q H F C P:20
. . . . . . G:
GTAAGAGAAGATTTTGTTTTAGTTAGAGGCAATTGGAGAGGATATTGTCGCAATTGTATT C:60
V R E D F V L V R G N W R G Y C R N C I P:20
. G:
CGTAAAGAATAA C:12
R K E P:3