HPV138 E6

Accession: H003374

NC: AEM24614.1

Protein: E6

Organism: Human papillomavirus type 13

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MESQCYSNVY LCMLHGCTL TLSVPCLFC RTLSHQDII FIVKCLRVV RDNSFYAAC
         .         .         .         .         .         .
SDCLRVSAAF LKQYCQCSA SDFVKLMCN DPTKLNVRC LCMKRLDCI ILDAFESEV
         .                                                  
EFFLIRSIWR KCRLCR