HPV137 E6
Accession: H003370
NC: YP_006393295.1
Protein: E6
Organism: Human papillomavirus type 13
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGAGCAGATATTTCCAACGAAGCTAAATGATTATTGCTCTTACTTTGAAATAAGTTTT C:60
M E Q I F P T K L N D Y C S Y F E I S F P:20
. . . . . . G:
TTTGACTTATCTTTAAAATGTATCTTCTGTAGACATTATTTGACTTTGGTAGATTTAGCA C:60
F D L S L K C I F C R H Y L T L V D L A P:20
. . . . . . G:
AAATTTCATGATAAAGACCTTTCTTTAGTTTGGAGGGGTAATATTTGTTATGCTTGTTGT C:60
K F H D K D L S L V W R G N I C Y A C C P:20
. . . . . . G:
GATAAATGTATTTGTTGTAGTGCTAGATACGAAGCTAATAAGCATTTTCAATGTACATTT C:60
D K C I C C S A R Y E A N K H F Q C T F P:20
. . . . . . G:
AAAACTGATAGTTTGCATTCTATAGTTCAGAAGCCTTTGCAAGAAATTGATATTCGTTGT C:60
K T D S L H S I V Q K P L Q E I D I R C P:20
. . . . . . G:
TATTACTGTTTACGTGTTTTAACATTGGTGGAAAAATTTGATTTGATTGCTCAAGGGAAG C:60
Y Y C L R V L T L V E K F D L I A Q G K P:20
. . . . . . G:
CCTACTTGTTTAATTAGAGGATACTTTAGAGCGCCTTGTACAGAGTGTTTGCGAAAAGAA C:60
P T C L I R G Y F R A P C T E C L R K E P:20
G:
TTGTATTAG C:9
L Y P:2