HPV140 E6
Accession: H003368
NC: YP_006393302.1
Protein: E6
Organism: Human papillomavirus type 14
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGGAGACTCTCTTCCCTACCAGTCTGGAGGCGTACTGCGACTACTTCAACATTAGCTTT C:60
M E T L F P T S L E A Y C D Y F N I S F P:20
. . . . . . G:120
TTTAAACTGCAATTGAAATGTATTTTCTGCAGGAATTATCTTACGCCTGTTGATCTAGCA C:60
F K L Q L K C I F C R N Y L T P V D L A P:20
. . . . . . G:180
TTATTTCATGTAAAGCAATTGAGTCTTGTATGGAAGGAGCGTATTTGCTATGCTTGTTGT C:60
L F H V K Q L S L V W K E R I C Y A C C P:20
. . . . . . G:240
AACAGATGCTTATTGCTTAGTGCAAAATTTGAAGCGGAAAAGTACTTTCAGTGTGCGTGT C:60
N R C L L L S A K F E A E K Y F Q C A C P:20
. . . . . . G:300
CCTGTAGAAACTTTGCATGCTTTATTAGAGAAACCTTTACAGGAAATTATATTACGCTGT C:60
P V E T L H A L L E K P L Q E I I L R C P:20
. . . . . . G:360
TACTATTGCTACTCACTGCTTGATTTACCTGAGAAGTTTGATTTGATATCTAGATCTAAG C:60
Y Y C Y S L L D L P E K F D L I S R S K P:20
. . . . . . G:420
CAGGCTTGCTTAGTAAGAGGGCACTGGAGAGCACCTTGCAGAAATTGTATCAAGCAGGAA C:60
Q A C L V R G H W R A P C R N C I K Q E P:20
. G:432
TTCTGGATTTAA C:12
F W I P:3