HPV135 E6
Accession: H003360
NC: YP_006393281.1
Protein: E6
Organism: Human papillomavirus type 13
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:177
ATGGAGGGTACACAACCTCGTAGCCTAGATGAATATTGTTCTGTTTTTAAAGTTGATTTT C:60
M E G T Q P R S L D E Y C S V F K V D F P:20
. . . . . . G:237
TTTAACGTACGACTGCGTTGTATTTTTTGTTTGTTTTATGCAAGCCTTACGGACCTTGCT C:60
F N V R L R C I F C L F Y A S L T D L A P:20
. . . . . . G:297
AATTTTTTTGATAAGAAATTGTCTATAGTGTGGAGGGGAGATACTCCTTATGTATGCTGT C:60
N F F D K K L S I V W R G D T P Y V C C P:20
. . . . . . G:357
ATAAGATGTGCGCGACATTCCGCTAAAATAGATAGAGAGAAGTATACTTTGTGTGCTGTC C:60
I R C A R H S A K I D R E K Y T L C A V P:20
. . . . . . G:417
AAATGTGATATTCTTGATGCTGTGGTTGGTAAGCCTTTAAAAGAAATTGTAATTCGTTGC C:60
K C D I L D A V V G K P L K E I V I R C P:20
. . . . . . G:477
TCTGCCTGTTTTGCGTTATTGGATCAAGCAGAAAAATTAGATGCTTGTGCCAGAGAACAG C:60
S A C F A L L D Q A E K L D A C A R E Q P:20
. . . . . G:534
CTTGTGTTACTCATTAGGGGACATTGGCGCACAGAGTGTAGACTTTGTAAAGTATGA C:57
L V L L I R G H W R T E C R L C K V P:18