HPV144 E6
Accession: H003357
NC: YP_006393309.1
Protein: E6
Organism: Human papillomavirus type 14
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGGCTGCTCTGTTTCCTGTGCGTCTTGATGAATACTGCAAAACTTTTAATATTCCTTTC C:60
M A A L F P V R L D E Y C K T F N I P F P:20
. . . . . . G:120
TTGGATCTTAAATTGTGCTGTATATTTTGTTCTCATTATATTGATATACGAGAGCTGGCT C:60
L D L K L C C I F C S H Y I D I R E L A P:20
. . . . . . G:180
GACTTCCACCAGAAAAAACTGTCCTTGATTTGGAGAAATTTTCAATGTTTTGCCTGTTGT C:60
D F H Q K K L S L I W R N F Q C F A C C P:20
. . . . . . G:240
GAGCGCTGTATCTTTTTGTCTGCTAGATATGAAAGAGAAAACTTTTTTCAATGTACAGTA C:60
E R C I F L S A R Y E R E N F F Q C T V P:20
. . . . . . G:300
AAGCCTGATGATTTAGCTTCTCTAGTTGAAAAGCCTTTACCTGAGGTGATTATTAGGTGT C:60
K P D D L A S L V E K P L P E V I I R C P:20
. . . . . . G:360
TATATATGTCTGGATTTGTTGGATGCAGCAGAAAAGCAAGATCATATTGCTAGAGGCAAA C:60
Y I C L D L L D A A E K Q D H I A R G K P:20
. . . . . . G:420
AGGTTTATATTAGTTAGAGGGCATTGGAGAGGGTACTGTAGAAGGTGCATGCAGAAAGAA C:60
R F I L V R G H W R G Y C R R C M Q K E P:20
G:423
TGA C:3
P:0