HPV145 E6

Accession: H003355

NC: AEM24663.1

Protein: E6

Organism: Human papillomavirus type 14

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MELPKPQTVR LGDRLSIPI DLLIPCRFC RFLPYIDLL FDYKTLQLI TEEDFVFAC
         .         .         .         .         .         .
CCSCAHASAQ EFTKFYEFS IGKELEQVE QHIGAIPVR HYCLRLLDL EKLEVCYTH
         .         .                                        
QQFHKVRGNW ARCRHCGVI