HPV146 E6

Accession: H003353

NC: AEM24670.1

Protein: E6

Organism: Human papillomavirus type 14

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MAAYFPRSLD YCKYFEIDF SLRLRCIFC FYTSPQDLA FYTKKLSIV RYNIPFACC
         .         .         .         .         .         .
TKCCKHSALV KQKYFQCSV CRILDAVVG PLAEIVIRC WCFALLDLA KVDLCARDD
         .                                                  
IALLIRGHWR DCRNCCTKE