HPV147 E6

Accession: H003351

NC: AEM24677.1

Protein: E6

Organism: Human papillomavirus type 14

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MASEQLRTLE YCSYFDCSF NVHLPCIFC CVLTAQDLA FACKNLSLV RNSQYFACC
         .         .         .         .         .         .
INCCRLSARH FDKYYQCHI SVNIETFSE RLHALCVRC NCLKKLDIA KYDVVCRDG
         .                                                  
YFHLVRSQWR LCRDCIPK