HPV5 E6
Accession: H003349
NC: NP_041365.1
Protein: E6
Organism: Human papillomavirus type 5
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:259
ATGGCTGAGGGAGCCGAACACCAACAGAAACTGACAGAAAAAGATAAGGCAGAATTACCT C:60
M A E G A E H Q Q K L T E K D K A E L P P:20
. . . . . . G:319
TTAAGTATTAGAGACTTAGCTGAAGCCTTAGGCATCCCTGTGATTGATTGTTTAATACCT C:60
L S I R D L A E A L G I P V I D C L I P P:20
. . . . . . G:379
TGCAATTTCTGTGGCAACTTTCTAAATTATTTGGAAGCTTGTGAATTCGACTACAAAAGG C:60
C N F C G N F L N Y L E A C E F D Y K R P:20
. . . . . . G:439
CTTAGTCTAATTTGGAAAGATTATTGTGTGTTTGCGTGCTGTCGCGTATGCTGTGGCGCC C:60
L S L I W K D Y C V F A C C R V C C G A P:20
. . . . . . G:499
ACTGCAACTTATGAATTTAACCAATTTTATGAGCAGACAGTGTTAGGAAGAGATATTGAA C:60
T A T Y E F N Q F Y E Q T V L G R D I E P:20
. . . . . . G:559
TTAGCTTCAGGACTTTCAATATTTGATATTGATATCAGGTGTCAAACTTGCTTAGCATTT C:60
L A S G L S I F D I D I R C Q T C L A F P:20
. . . . . . G:619
CTTGACATTATAGAAAAGTTAGATTGCTGTGGCAGAGGCCTTCCCTTTCATAAGGTGAGG C:60
L D I I E K L D C C G R G L P F H K V R P:20
. . . . . G:673
AACGCCTGGAAGGGAATCTGTAGGCAGTGTAAGCATTTTTATCATGATTGGTAA C:54
N A W K G I C R Q C K H F Y H D W P:17