HPV85 E6

Accession: H003290

NC: AAD24181.1

Protein: E6

Organism: Human papillomavirus type 85

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MAEFGNPATR YKLPDLCNT DTSLQDIEI CVYCKSVLQ TEVYEFAFA LFVVYRDGI
         .         .         .         .         .         .
PYAACQNCLM YSKIRELRY SDSVYGETL KLTNSNIYD LIRCLRCQK LCPAEKLKH
         .         .         .                              
LNEKRRFHKI GKYRGQCRR MTRAQEQQG RRETQV