HPV90 E6
Accession: H003288
NC: NP_671503.1
Protein: E6
Organism: Human papillomavirus type 90
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGACCAACGGAGACTACTGCCCAAGAAATATCTTCCTATTGTGCAAAGTCTATGAACTG C:60
M T N G D Y C P R N I F L L C K V Y E L P:20
. . . . . . G:120
GACCTGCAGGACCTGAACATAACCTGCGTGTTTTGCGGAACAGCATTAACAGAGGAGGAG C:60
D L Q D L N I T C V F C G T A L T E E E P:20
. . . . . . G:180
GTTGTATCGTTTGCATACAAGGAGCTACAAGTTGTGTGGAGAAAGCATTTTCCATTTGCA C:60
V V S F A Y K E L Q V V W R K H F P F A P:20
. . . . . . G:240
GCATGTCCTGCGTGTCTGGAAGCAGCCGGGAAACTAAGGCAATTTAGATACTGGCAGTAT C:60
A C P A C L E A A G K L R Q F R Y W Q Y P:20
. . . . . . G:300
TCTAGCTATGCACCCACAGTGGAATATGAAACAGGAGTGCCTATTTTAGAATTGCTTATT C:60
S S Y A P T V E Y E T G V P I L E L L I P:20
. . . . . . G:360
AGATGCTACCTGTGCCATAAACCACTGTGCAGTGAGGAAAAGGAACGGCTTATCAGTGAA C:60
R C Y L C H K P L C S E E K E R L I S E P:20
. . . . . . G:420
GGCAAACGGTTCCATAAAATAGCTGGGCTTTGGCGAGGCGCTTGCCTGCAGTGTTGGAAA C:60
G K R F H K I A G L W R G A C L Q C W K P:20
. . G:447
CCATGCATGGCCAACGACCAACCTTAA C:27
P C M A N D Q P P:8