HPV126 E6
Accession: H003260
NC: YP_004934012.1
Protein: E6
Organism: Human papillomavirus type 12
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:156
ATGGATCAGCAATTTCCTACCTCGTTGGATGTGTACTGCGATACATTTGGGATATCTTTT C:60
M D Q Q F P T S L D V Y C D T F G I S F P:20
. . . . . . G:216
TTCTGTTTAAAATTAAAATGTATTTTCTGTGGGTCATGGCTTAGCCTAACAGAATTAGCA C:60
F C L K L K C I F C G S W L S L T E L A P:20
. . . . . . G:276
GAATTCTTTGAAAAGCATCTTTCGTTGGTCTGGAAAAATAATATATGTCACGCCTGCTGT C:60
E F F E K H L S L V W K N N I C H A C C P:20
. . . . . . G:336
TTAAAATGTTTGTGCTTGAGTGCAAGATATGAAACTGAGAATTATTTTCAGTGTGCTTGT C:60
L K C L C L S A R Y E T E N Y F Q C A C P:20
. . . . . . G:396
GAAGTGGAAAATCTGAGTGGATTGTTAAACAAGCCATTGGAGGATATTATTATCAGATGC C:60
E V E N L S G L L N K P L E D I I I R C P:20
. . . . . . G:456
TATTTTTGTTTAGCTTTGGTTGATTTGCCTACTAAATGTGATCTTATTGCCAGAAAGAAA C:60
Y F C L A L V D L P T K C D L I A R K K P:20
. . . . . . G:516
CCAGCTTGTTTAGTTAGAGGGCATTGGAGAGCTCCTTGCAGACGCTGTTTAAATAGAGAA C:60
P A C L V R G H W R A P C R R C L N R E P:20
. G:528
CTGTGGCTGTAA C:12
L W L P:3