HPV63 E6
Accession: H003098
NC: NP_040896.1
Protein: E6
Organism: Human papillomavirus type 63
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGACCTGACATCTGTACATTCGGTTCGGGATCTGAGTTCTGCTCTCCGTATCCCATTT C:60
M D L T S V H S V R D L S S A L R I P F P:20
. . . . . . G:221
ATTGATTTGGTTGTTCCTTGCAATTTTTGCTTGAAATTTCTTACAAATGCTGAAAAATTG C:60
I D L V V P C N F C L K F L T N A E K L P:20
. . . . . . G:281
CTGTTTGATTATTTTGACTTGCATCTTATCTGGCGAGATAATTTCGTGTTTGCTTGTTGT C:60
L F D Y F D L H L I W R D N F V F A C C P:20
. . . . . . G:341
CAGTGCTGTGCTAGGCATGTTAGTCTGCTTGAGTTTATGCTTTATTATCAGGAGTCTTTC C:60
Q C C A R H V S L L E F M L Y Y Q E S F P:20
. . . . . . G:401
GAGGTATCTGAAGTAGAAGAATTACTTAATCAACCTCTTGTAAATATTGGTTTAAGGTGT C:60
E V S E V E E L L N Q P L V N I G L R C P:20
. . . . . . G:461
GTTACATGCACAAAAAAACTGACTGTTTCAGAAAAGTTAGCTGTTGTTTCTGCTGGAGAA C:60
V T C T K K L T V S E K L A V V S A G E P:20
. . . . . . G:521
AGAGTTCATAAAGTAAGGAACAAATTCAAAGCAAAGTGCAGTTTGTGCAGACTCTACATT C:60
R V H K V R N K F K A K C S L C R L Y I P:20
G:527
ATATAG C:6
I P:1