HPV4 E6
Accession: H003091
NC: NP_040889.1
Protein: E6
Organism: Human papillomavirus type 4
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGCAGATGGCAGACCTGCAACCTTGGACGACTTCTGCAGACGATTCGACATTTCCTTT C:60
M A D G R P A T L D D F C R R F D I S F P:20
. . . . . . G:221
TTTGATTTGCGCCTTACTTGTATTTTTTGTTCTCATACTGTCGATCTTGCGGATCTTGCT C:60
F D L R L T C I F C S H T V D L A D L A P:20
. . . . . . G:281
TTATTCTATCTTAAGAAACTTAGTTTAGTATTTAGAGGAAATTGTTATTATGCATGTTGT C:60
L F Y L K K L S L V F R G N C Y Y A C C P:20
. . . . . . G:341
TCTGAATGCTTAAGATTAAGTGCACTGTTTGAACAAGAGAATTATTTTCAATGTTCTATT C:60
S E C L R L S A L F E Q E N Y F Q C S I P:20
. . . . . . G:401
AAAGCTGTACATTTGGAGGAAATTGCTCAGAAAAAGATTAAGGAAATTTGCATTAGATGC C:60
K A V H L E E I A Q K K I K E I C I R C P:20
. . . . . . G:461
ATTTGCTGCCTTAGATTACTTGATATTGTTGAGAAATTAGATTTATTATACTCTGACGAG C:60
I C C L R L L D I V E K L D L L Y S D E P:20
. . . . . . G:521
ACTTGCTATTTAATAAGGGGTTTGTGGAGGGGCTATTGCAGAAATTGTATTAGGAAACAA C:60
T C Y L I R G L W R G Y C R N C I R K Q P:20
G:524
TGA C:3
P:0