HPV41 E6
Accession: H003085
NC: NP_040285.1
Protein: E6
Organism: Human papillomavirus type 41
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGCATCAACAAGCGGTGTGGGATCCGTCGGGCCTGCAAGCTGTTGCGAGACGCAGAAG C:60
M A S T S G V G S V G P A S C C E T Q K P:20
. . . . . . G:221
CCACATACCATACGGGAGTTGTGTTTGGCGCAGCAGATAACTTATCCATGCATACAGCTC C:60
P H T I R E L C L A Q Q I T Y P C I Q L P:20
. . . . . . G:281
TGCTGCCATTATTGCTATAAGATCCTTAGCGTATTGGATATTTACGCTTTCGACCAGAGC C:60
C C H Y C Y K I L S V L D I Y A F D Q S P:20
. . . . . . G:341
TGTCTGTACTTATCCTGGGGAGAAGGGGGGCCAACGGGTATTTGTTCTCAGTGTACTAGA C:60
C L Y L S W G E G G P T G I C S Q C T R P:20
. . . . . . G:401
GTGCTTGCAAGGCTGGAGTTCACTGCACGGCACGAAGTGTCTTGTGCAGCCAGCCGTCTG C:60
V L A R L E F T A R H E V S C A A S R L P:20
. . . . . . G:461
CCGCACTTTATAGGACAGAGCCTCAGCGACCTTGAGGTGAGGTGTGTGAGGTGCCTAGCT C:60
P H F I G Q S L S D L E V R C V R C L A P:20
. . . . . . G:521
CTTCTACAATCTGTGGAAAAGGATTACATATTGCGGGAAGACTTGTCTGTGCATAGAATT C:60
L L Q S V E K D Y I L R E D L S V H R I P:20
. . . . . G:572
GGCGGGATCTGGAGGGGAACTTGTGTTCGATGTATGGTAGGACTGTATTAG C:51
G G I W R G T C V R C M V G L Y P:16