HPV2 E6

Accession: H003050

NC: NP_077116.1

Protein: E6

Organism: Human papillomavirus type 2

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHTRAGMSEE PCPRNIFLL KEYGLELED RLLCVWCKR LSEADIWAF IKELFVVWR
         .         .         .         .         .         .
KGFPFGACGK LIAAGKLRQ RHWHYSCYG TVETETGIP PQLFMRCYI HKPLSWEEK
         .         .         .                              
EALLVGNKRF NISGRWTGH MNCGSSCTA DPASRTLH