HPV9 E6
Accession: H003036
NC: NP_041860.1
Protein: E6
Organism: Human papillomavirus type 9
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:280
ATGTATTTAACAGAGCAGATTATGGACAGGCCAAAACCTAGAACAGTAAAGGAACTAGCA C:60
M Y L T E Q I M D R P K P R T V K E L A P:20
. . . . . . G:340
GACACTCTTGTGATTCCTTTAATAGATTTGTTGATACCTTGTAAATTTTGCAATAGATTT C:60
D T L V I P L I D L L I P C K F C N R F P:20
. . . . . . G:400
TTATCTTATTTTGAGCTACTTAATTTTGATCACAAGTGTTTACAGCTTATTTGGACAGAG C:60
L S Y F E L L N F D H K C L Q L I W T E P:20
. . . . . . G:460
GAGGATTTGGTGTATGGACTCTGTAGTAGCTGTGCTTATGCGTCTGCACAGTTAGAATTT C:60
E D L V Y G L C S S C A Y A S A Q L E F P:20
. . . . . . G:520
ACACATTTTTTTCAATTTGCTGTAGTTGGAAAAGATATAGAAACTGTAGAAGGAACAGCT C:60
T H F F Q F A V V G K D I E T V E G T A P:20
. . . . . . G:580
ATTGGAAATATTTGTATTAGGTGTCGCTACTGTTTTAAGTTATTAGACTTAGTGGAGAAG C:60
I G N I C I R C R Y C F K L L D L V E K P:20
. . . . . . G:640
TTAGCTACATGCTATAAGTTTGAGCAGTTTTATAAGGTCAGAAACAGCTGGAAAGGATTG C:60
L A T C Y K F E Q F Y K V R N S W K G L P:20
. . G:646
TGCAGACACTGTGGGTCGGTAGAATGA C:27
C R H C G S V E P:8