HPV34 E6
Accession: H003022
NC: NP_041807.1
Protein: E6
Organism: Human papillomavirus type 34
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGTTTTTTCCCAATCCTGAGGAACGGCCATACAAGCTACCAGCCTTATGTGAAGAGGTC C:60
M F F P N P E E R P Y K L P A L C E E V P:20
. . . . . . G:221
AACATTTCAATACATGAAATAGAATTGGACTGTGTGTATTGCGAACGACAACTGTACAGA C:60
N I S I H E I E L D C V Y C E R Q L Y R P:20
. . . . . . G:281
TGTGAGGTATATGATTTTATATTTAGAGATTTATGTGTTGTATATAGAAAGGGGAAACCA C:60
C E V Y D F I F R D L C V V Y R K G K P P:20
. . . . . . G:341
CTTGGGGTATGTCAACCGTGTTTACTGTTTTACTCAAAGGTTAGACAATATAGAAGATAT C:60
L G V C Q P C L L F Y S K V R Q Y R R Y P:20
. . . . . . G:401
AACCAATCAGTGTATGGACGGACGTTAGAGAATTTAACTAACAAACAGTTGTGTAATATT C:60
N Q S V Y G R T L E N L T N K Q L C N I P:20
. . . . . . G:461
TTAATAAGGTGCGGAAAATGCCAAAAACCACTGTGTCCATTGGAAAAGCAAAGGCATGTA C:60
L I R C G K C Q K P L C P L E K Q R H V P:20
. . . . . . G:521
GATGAAAACAAACGGTTTCACCAAATAGCGGATCAGTGGACCGGACGCTGTACACAGTGC C:60
D E N K R F H Q I A D Q W T G R C T Q C P:20
. . G:548
TGGAGACCATCTGCAACAGTGGTGTAA C:27
W R P S A T V V P:8