HPV6 E6
Accession: H002961
NC: NP_040296.1
Protein: E6
Organism: Human papillomavirus type 6
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGAAAGTGCAAATGCCTCCACGTCTGCAACGACCATAGACCAGTTGTGCAAGACGTTT C:60
M E S A N A S T S A T T I D Q L C K T F P:20
. . . . . . G:
AATCTATCTATGCATACGTTGCAAATTAATTGTGTGTTTTGCAAGAATGCACTGACCACA C:60
N L S M H T L Q I N C V F C K N A L T T P:20
. . . . . . G:
GCAGAGATTTATTCATATGCATATAAACACCTAAAGGTCCTGTTTCGAGGCGGCTATCCA C:60
A E I Y S Y A Y K H L K V L F R G G Y P P:20
. . . . . . G:
TATGCAGCCTGCGCGTGCTGCCTAGAATTTCATGGAAAAATAAACCAATATAGACACTTT C:60
Y A A C A C C L E F H G K I N Q Y R H F P:20
. . . . . . G:
GATTATGCTGGATATGCAACAACAGTTGAAGAAGAAACTAAACAAGACATCTTAGACGTG C:60
D Y A G Y A T T V E E E T K Q D I L D V P:20
. . . . . . G:
CTAATTCGGTGCTACCTGTGTCACAAACCGCTGTGTGAAGTAGAAAAGGTAAAACATATA C:60
L I R C Y L C H K P L C E V E K V K H I P:20
. . . . . . G:
CTAACCAAGGCGCGGTTCATAAAGCTAAATTGTACGTGGAAGGGTCGCTGCCTACACTGC C:60
L T K A R F I K L N C T W K G R C L H C P:20
. . . G:
TGGACAACATGCATGGAAGACATGTTACCCTAA C:33
W T T C M E D M L P P:10