HPV49 E6
Accession: H002957
NC: NP_041832.1
Protein: E6
Organism: Human papillomavirus type 49
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:259
ATGGCTAGACCTGTTAAGGTATGTGAGCTAGCCCACCACTTAAATATACCTATTTGGGAA C:60
M A R P V K V C E L A H H L N I P I W E P:20
. . . . . . G:319
GTTTTGCTTCCTTGTAATTTTTGCACGGGGTTTCTAACATATCAGGAGTTGTTAGAATTT C:60
V L L P C N F C T G F L T Y Q E L L E F P:20
. . . . . . G:379
GACTATAAAGACTTTAATTTGCTGTGGAAAGACGGATTTGTCTTTGGTTGTTGTGCAGCT C:60
D Y K D F N L L W K D G F V F G C C A A P:20
. . . . . . G:439
TGTGCCTATAGATCAGCATATCACGAGTTTACTAATTATCACCAAGAAATTGTCGTAGGC C:60
C A Y R S A Y H E F T N Y H Q E I V V G P:20
. . . . . . G:499
ATCGAAATAGAAGGACGAGCAGCGGCTAATATTGCTGAGATAGTAGTCAGATGTCTCATT C:60
I E I E G R A A A N I A E I V V R C L I P:20
. . . . . . G:559
TGCCTTAAGAGGCTAGATTTGTTGGAAAAGCTTGATATTTGTGCACAGCACAGAGAGTTT C:60
C L K R L D L L E K L D I C A Q H R E F P:20
. . . . . G:616
CACAGAGTTAGAAATAGGTGGAAAGGGGTGTGTAGACATTGCAGAGTTATAGAATGA C:57
H R V R N R W K G V C R H C R V I E P:18