HPV100 E6

Accession: H002953

NC: CAW42235.1

Protein: E6

Organism: Human papillomavirus type 100

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MYLRRMCCAK FMEPRPLTV HLSDKLTVP EDLLVPCRF NRFLTYLEL QFDYKFLHL
         .         .         .         .         .         .
IWTEEDFVFA CGGCAFASA FEYQQYYQG VYGRDIEQL QKPIGEIPI CQYCLKFLD
         .         .         .                              
LTEKLDICCL QAFHKVRNH KGRCRHCKA E