HPV109 E6
Accession: H002948
NC: YP_002756538.1
Protein: E6
Organism: Human papillomavirus type 109
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGATTCTGTAAATTCTCTGTTTGATCTTTGTGATTTGTATGGCTGTACTCTGGAAACT C:60
M D S V N S L F D L C D L Y G C T L E T P:20
. . . . . . G:
TTATGTGTGTCTTGCTTGTTTTGTAAATCTAATCTTTCCTATCAAGATCTTCTTGCCTTT C:60
L C V S C L F C K S N L S Y Q D L L A F P:20
. . . . . . G:
ATTGTTAAAAATCTTAAAGTTGTCTATCGAAATTTTGCATTTCATGCTGCATGTACATCT C:60
I V K N L K V V Y R N F A F H A A C T S P:20
. . . . . . G:
TGTCTTAAACTTACTGCATTACATGAACAAAGATTGTATTGTCAATGTACTGCTAGTGCT C:60
C L K L T A L H E Q R L Y C Q C T A S A P:20
. . . . . . G:
GCTTATGTCCAATATGTTTGTAATGGTGATATAGCTTCTTTAAATGTTAGATGTGTGGCT C:60
A Y V Q Y V C N G D I A S L N V R C V A P:20
. . . . . . G:
TGTATGAAACAATTGGATTGCATTGAAAAGCTGGATTGTATTCAAAAGGAGCAAACATTT C:60
C M K Q L D C I E K L D C I Q K E Q T F P:20
. . . . . . G:
TTTTTAATAAGGAGTATCTGGCGTTGTTTCTGTAGACTTTGTCAAACTCAGGATGCATGG C:60
F L I R S I W R C F C R L C Q T Q D A W P:20
G:
TAA C:3
P:0