HPV88 E6
Accession: H002941
NC: YP_001672008.1
Protein: E6
Organism: Human papillomavirus type 88
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:136
ATGCAGATGGAGGATTCTTATCTACCAAAACGGCTAGATGACTTCTGTTCGATTTTTAAT C:60
M Q M E D S Y L P K R L D D F C S I F N P:20
. . . . . . G:196
ATTTCTCTTTTTGATGTGCATCTTCCTTGCATATTTTGTGGCTATATTTTGGACCTACAG C:60
I S L F D V H L P C I F C G Y I L D L Q P:20
. . . . . . G:256
CAGTTGGGTTCGTTCTATCAGAAACAGCTTAGTTTGGTCTGGAGGAGCGGTGCTTGTTTT C:60
Q L G S F Y Q K Q L S L V W R S G A C F P:20
. . . . . . G:316
GCGTGTTGTGTCCCTTGTTCTAGGCTTTCTGCTAGGTATGAGGCTGAACGCTTTTACCGC C:60
A C C V P C S R L S A R Y E A E R F Y R P:20
. . . . . . G:376
TGCTCTGTAAAGGGAATTCATTTTGAGGATTTCCTAAGAAAGAATCTAGCTGATGTGGTA C:60
C S V K G I H F E D F L R K N L A D V V P:20
. . . . . . G:436
TGCCGATGCTATGAATGTATGTCATTGCTTGATTTACCTGAAAAATTAGATTGTATCTTT C:60
C R C Y E C M S L L D L P E K L D C I F P:20
. . . . . . G:496
AGGGGTGAGTGTTTCCATCTTGTGAGAAACACTTGGAGGGGAACGTGCAGAAATTGTTGT C:60
R G E C F H L V R N T W R G T C R N C C P:20
G:505
AGAAAATGA C:9
R K P:2