HPV99 E6

Accession: H002940

NC: CAW42225.1

Protein: E6

Organism: Human papillomavirus type 99

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MEGQAEQNKI NTLSELPST KGLAQALGI LVDCLLPCN CGKFLDFLE CDFDKKQLN
         .         .         .         .         .         .
LIWKDYVVTA CRCCSVATA FEFNEFYEQ VLGRDIELA GRSIFEIDV CQNCLSFLD
         .         .         .                              
IIEKLDCCGR RPFHKVRGA KAVCRLCKH YNDW