HPV92 E6
Accession: H002934
NC: NP_775305.1
Protein: E6
Organism: Human papillomavirus type 92
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:165
ATGGCAAAACCTCCTTCGGTGCAGGAACTTAGAAGACAGTTAGATATTCCATTGGAGGAC C:60
M A K P P S V Q E L R R Q L D I P L E D P:20
. . . . . . G:225
ATTTTATTGCATTGTAATTTTTGTGAGGCTTTTTTAACATTTGAGGAGCTACTGCAATTT C:60
I L L H C N F C E A F L T F E E L L Q F P:20
. . . . . . G:285
GATGCAAAAAATTTAAATTTAATTTGGAAGGAGAATTATGCTTATGCTTGCTGTGGTGCT C:60
D A K N L N L I W K E N Y A Y A C C G A P:20
. . . . . . G:345
TGTGCTAAACAAGTAGCAGCAATAGAAACAAAACATTTTTATGAGTATAGTGTACAAGGA C:60
C A K Q V A A I E T K H F Y E Y S V Q G P:20
. . . . . . G:405
AAGGATGCTATAGAAAGGGACTCAGGTAGTCTTTTGTGTTGTTTAACTGTTAGATGTAAG C:60
K D A I E R D S G S L L C C L T V R C K P:20
. . . . . . G:465
TTTTGTTTAAGACATTTGGATTACTTAGAGAAATTGGCAGTTTGTGCATCAGGCATTCCT C:60
F C L R H L D Y L E K L A V C A S G I P P:20
. . . . . G:522
TTTGATAGAGTTAGAGGAGCTTGGAAGGCAGTGTGTAGGTTTTGTACAGAGATATGA C:57
F D R V R G A W K A V C R F C T E I P:18