HPV96 E6
Accession: H002932
NC: NP_932319.1
Protein: E6
Organism: Human papillomavirus type 96
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:148
ATGCAGTATCTGATCCTGGCAGTCACTCCTGGAACAACACCGATCCAGTGGCTTTGCCAA C:60
M Q Y L I L A V T P G T T P I Q W L C Q P:20
. . . . . . G:208
AAGCAGTTTAAACCTGCCAAGAAAAGCCCGCCAAAACGTCTGCCAACTTTGGAACCGTTA C:60
K Q F K P A K K S P P K R L P T L E P L P:20
. . . . . . G:268
ACGGTAAGTTTCGCAACTCTCTCGGTTGCCAAAAGTTTTATCTTGAGAGGTTGTTGGCAA C:60
T V S F A T L S V A K S F I L R G C W Q P:20
. . . . . . G:328
TTACAACCTGCCACTCATAAACAAGTAACCGCCTGCGTTTCTAGGACATTTTATATACAG C:60
L Q P A T H K Q V T A C V S R T F Y I Q P:20
. . . . . . G:388
ACATACAGATCTCTGTTCATTGTTGAGATGGATTTAAAGACAGTGCAGCAACTTAGAAGT C:60
T Y R S L F I V E M D L K T V Q Q L R S P:20
. . . . . . G:448
CATTTGGGCATTCCTACTGAAGACCTGTTGTTAGCCTGTAACTTCTGTAAGAAATTTTTA C:60
H L G I P T E D L L L A C N F C K K F L P:20
. . . . . . G:508
ACCTTTGAGGAGCTATTAGGATTTGATAGCAAGACTTTAAATCTTATTTGGAAGGAAGGT C:60
T F E E L L G F D S K T L N L I W K E G P:20
. . . . . . G:568
TATGCATATGCGTGTTGTTTCAATTGTGCTAGAACAGTAGCCAAAGTAGAATTTGAACAT C:60
Y A Y A C C F N C A R T V A K V E F E H P:20
. . . . . . G:628
TTTTATGAAAAAACAGTCAAGGGACGAGAAATAGAATCTCGCAGTGGCAGTTTACTTTGT C:60
F Y E K T V K G R E I E S R S G S L L C P:20
. . . . . . G:688
TGTATTGTTGTTAGATGCCAGTTTTGTTTGCGACTGTTAGATTATTTAGAAAAGTTAAAT C:60
C I V V R C Q F C L R L L D Y L E K L N P:20
. . . . . . G:748
ATTTGTGGGTATCAAGAAAACTTTTATTTAGTAAGAGGAGGTTGGAAAGGCATTTGCAGA C:60
I C G Y Q E N F Y L V R G G W K G I C R P:20
. G:766
TATTGTAGAGAGATATGA C:18
Y C R E I P:5