HPV128 E6
Accession: H002931
NC: YP_004169263.1
Protein: E6
Organism: Human papillomavirus type 128
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGCTTCTTTGCAACCCACCCGCTTAAATGAGTATTGTAAACTGCATAGTATTGATTTT C:60
M A S L Q P T R L N E Y C K L H S I D F P:20
. . . . . . G:
TTTGATCTTAGGCTGCGTTGTATTTTTTGTCAATTCATATGTTCTTTGGAAGACCTTGCT C:60
F D L R L R C I F C Q F I C S L E D L A P:20
. . . . . . G:
TCTTTTTTTGAGAAGAATTTAAGCTTGGTGTATAGAAATAATTTACCTTTTGCTTGTTGT C:60
S F F E K N L S L V Y R N N L P F A C C P:20
. . . . . . G:
ATGAAATGTCTTAAACAAACTGCGATTTATGAAAGAGAAAGGTTTTGTCAATGTACTGTT C:60
M K C L K Q T A I Y E R E R F C Q C T V P:20
. . . . . . G:
AAAAGTTCTATTATTGATGTTGTTACTGGTAAATCTTTACAAGATTTAATTGTTAGATGT C:60
K S S I I D V V T G K S L Q D L I V R C P:20
. . . . . . G:
TTATATTGCTTTGCTTTGTTGGATTCTATTGAAAAAAGGGAGTGTCTAAATAGAGATGAA C:60
L Y C F A L L D S I E K R E C L N R D E P:20
. . . . . . G:
GATTTGTGTTTAGTGAGAGGTCACTGGAGATGGTATTGTAGGAACTGCTTTTCTTTACAT C:60
D L C L V R G H W R W Y C R N C F S L H P:20
. G:
TATGAGGGGTAA C:12
Y E G P:3