HPV129 E6
Accession: H002929
NC: YP_004169270.1
Protein: E6
Organism: Human papillomavirus type 129
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGTGGAAGATTCAGCAGTTTTTGCCACACCTGATGGAGAACCTATTTCCTACGGGCCTG C:60
M W K I Q Q F L P H L M E N L F P T G L P:20
. . . . . . G:120
CGAGATTATTGTAGCTACTTTGATATTCCGTTTTTTGACTTAAAACTACCATGTATATTC C:60
R D Y C S Y F D I P F F D L K L P C I F P:20
. . . . . . G:180
TGTAAAAATATTTGCAACTTGGTAGATTTAGCACAATTTTTTGAAAAGAAATTGTGCATA C:60
C K N I C N L V D L A Q F F E K K L C I P:20
. . . . . . G:240
GTTTGGAGACAACATGTAGCGCACGCATGTTGTGAGAAATGCTTAACGCTGTGTGCGAGA C:60
V W R Q H V A H A C C E K C L T L C A R P:20
. . . . . . G:300
TATGGATCGGAGCATCATTGTGTGTGCTCTGTCAAAGCAGAAAATTTGCATGGATTAATT C:60
Y G S E H H C V C S V K A E N L H G L I P:20
. . . . . . G:360
CGTCAGCCTTTGCAAAATATTTTATTAAGATGTAATTATTGTTTTCGCGTTTTGACTGCA C:60
R Q P L Q N I L L R C N Y C F R V L T A P:20
. . . . . . G:420
TCAGAGAAAGTGGATTTAGTAACTGGAGGACGGTATTGCTGGCTTGTAAGAGGACATTGG C:60
S E K V D L V T G G R Y C W L V R G H W P:20
. . . G:459
AGAGCCATTTGTAGTCTGTGTGCTACTAAGGAGCTTTGA C:39
R A I C S L C A T K E L P:12