HPV130 E6

Accession: H002928

NC: ADQ85950.1

Protein: E6

Organism: Human papillomavirus type 130

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MDTFLSPTPV ITAYCSTFG TLEQVRIPC FCKGYLNVQ CAAFDLKKF LLWKNGFCF
         .         .         .         .         .         .
ACCRSCMRLS AFESSHFKQ ICNCNFVVD VQKPLREIP RCIECLAFL YSEKIQHLL
         .         .                                        
LNENFTLVRS WRGYCRNCI KE