HPV131 E6
Accession: H002927
NC: YP_004169277.1
Protein: E6
Organism: Human papillomavirus type 131
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:
ATGGCTTCCACATATCCTAACAATTTGGTCGATCTTTGCTCTGCTTGTAATATAAGCTTC C:60
M A S T Y P N N L V D L C S A C N I S F P:20
. . . . . . G:
TTTAACTTGCATTTAGATTGTTTATTTTGTAAACATAAATTAACAATTCTTGATTTAGCA C:60
F N L H L D C L F C K H K L T I L D L A P:20
. . . . . . G:
GGATTTCATCAAAAGCAATTGTCCGTTGTTTGGAGGAATGATAAAGCGTTTGGGTCTTGT C:60
G F H Q K Q L S V V W R N D K A F G S C P:20
. . . . . . G:
TCAAAATGTTTGCGATTGACTGCTAATTACGAAAGAGAAAATTATTACAGATGTTCTGTT C:60
S K C L R L T A N Y E R E N Y Y R C S V P:20
. . . . . . G:
AAAGGTTCATTAATATCTGGATTGTTAAAAACTCCTTTAAAAGACATTACTGTTCGTTGT C:60
K G S L I S G L L K T P L K D I T V R C P:20
. . . . . . G:
TTGTATTGCTTTCAATTACTTGATTTAATAGAAAAAACTCAGCATCATTTGGGAGATAGA C:60
L Y C F Q L L D L I E K T Q H H L G D R P:20
. . . . . . G:
GATTTTCATCTTGTAAGAAACCATTGGAGAGGGTGTTGTAGAAATTGTTATAGTTATGAG C:60
D F H L V R N H W R G C C R N C Y S Y E P:20
G:
GGGTGA C:6
G P:1