HPV132 E6
Accession: H002925
NC: YP_004169284.1
Protein: E6
Organism: Human papillomavirus type 132
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGGAGACATACCGACCCTCGAATGTGGCTGAATATTGCGCATTTTATAACCTGAACTTT C:60
M E T Y R P S N V A E Y C A F Y N L N F P:20
. . . . . . G:120
ACTGATGTGGGAATGCGATGTTGCTTTTGTAAGGCATGGTTAAATTGTGTGGAATTAGCC C:60
T D V G M R C C F C K A W L N C V E L A P:20
. . . . . . G:180
AGTTTTCACTATAAAAGCTTAAGTTTGTTATGGAGAGATAATAATGTTTTTGCATGTTGT C:60
S F H Y K S L S L L W R D N N V F A C C P:20
. . . . . . G:240
TGCCAATGTTTGCGTTTATCAGCAAAATATGAGATGGAAAGATTTTATCGCTGTTCTGTT C:60
C Q C L R L S A K Y E M E R F Y R C S V P:20
. . . . . . G:300
AAAGCAAAGATAATTGAAGATGTTGTGCAAACACCTTTAATTGAAATTGTAATTCGTTGC C:60
K A K I I E D V V Q T P L I E I V I R C P:20
. . . . . . G:360
TTTCATTGCTTTGCATTGTTGGATTTAATTGAAAAGATAGAGCATAAATATAGAGATGAC C:60
F H C F A L L D L I E K I E H K Y R D D P:20
G:420
TCGTTTCATTTAGTAAGGCATTTTTGGAGAGGAGAGTGCAGACATTGTTGCAGAAAATGA C:0
S F H L V R H F W R G E C R H C C R K P:19