HPV134 E6
Accession: H002924
NC: YP_004169291.1
Protein: E6
Organism: Human papillomavirus type 134
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:60
ATGGAACCAGTCTATTCTATTCCTGCTCTATGTCGTCTCTGTAGAGTAACGATTGATAGA C:60
M E P V Y S I P A L C R L C R V T I D R P:20
. . . . . . G:120
TTACATTTGCCTTGTTTGTTTTGCCATAATGTACTTTCTTTGGGTGATCTGTATAGTTTT C:60
L H L P C L F C H N V L S L G D L Y S F P:20
. . . . . . G:180
ATGTTTAAGGATTTAAATGTTGTTATTAGAGGTTATAGACTGTTTGCATGCTGTGTAAAT C:60
M F K D L N V V I R G Y R L F A C C V N P:20
. . . . . . G:240
TGTTTATTAATTTCAGCTAATTATGAAATGCAACAATATTATCAATGTACTGCTAATGCA C:60
C L L I S A N Y E M Q Q Y Y Q C T A N A P:20
. . . . . . G:300
TCTACTGTTCAGTGTTTAACTAGAAAATCTTTGTTGTTTCTGTATGTTAGATGTGATGTG C:60
S T V Q C L T R K S L L F L Y V R C D V P:20
. . . . . . G:360
TGTATGAAACCTTTATCAGCTACAGAAAAGTTTGATTGTCTTACTAAAAATGATGAGATG C:60
C M K P L S A T E K F D C L T K N D E M P:20
. . . . . G:414
CATTTAGTAAGATCTATTTGGAGAGGTACATGTAGATTATGTAGGAAAAAATAA C:54
H L V R S I W R G T C R L C R K K P:17