HPV149 E6

Accession: H002923

NC: ADQ85943.1

Protein: E6

Organism: Human papillomavirus type 149

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MEPPGSIYSL DIYGCTLEN TICCLFCRT LSYKDILSF VKQLRVVIR NTFFAACCT
         .         .         .         .         .         .
CLQLSAAYER TYCQCIATA FVKYVCNGD CNLNVRCVK IKRLDLPEV ECLENNSPF
         .                                                  
YLVRCIWRSE RLCRN