HPV2 E6
Accession: H002787
Protein: E6
Organism: Human papillomavirus type 2
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:148
atgcacacaagggcagggatgtctgaggagaatccatgccctaggaacatctttttgctt C:60
M H T R A G M S E E N P C P R N I F L L P:20
. . . . . . G:208
tgcaaagagtatggtttggagctagaggatttgcgattgctctgtgtatggtgcaaacgg C:60
C K E Y G L E L E D L R L L C V W C K R P:20
. . . . . . G:268
ccgttatcagaggctgacatatgggcatttgcaataaaagaactgtttgtagtgtggaga C:60
P L S E A D I W A F A I K E L F V V W R P:20
. . . . . . G:328
aagggcttcccatttggagcctgcggaaaatgcctgattgcagcaggaaaacttagacaa C:60
K G F P F G A C G K C L I A A G K L R Q P:20
. . . . . . G:388
tacagacattggcattactcatgctacggagacacagtggagactgagacaggaataccc C:60
Y R H W H Y S C Y G D T V E T E T G I P P:20
. . . . . . G:448
atacctcagctgtttatgagatgctatatttgccataagcccctgagctgggaggagaag C:60
I P Q L F M R C Y I C H K P L S W E E K P:20
. . . . . . G:508
gaggcattactagttggaaacaagcgtttccacaacatatcaggccggtggacgggacat C:60
E A L L V G N K R F H N I S G R W T G H P:20
G:568
tgcatgaactgcgggtcatcatgcacggcaaccgacccagcctcaaggacattacactaa C:0
C M N C G S S C T A T D P A S R T L H P:19